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首页> 外文期刊>Neuropsychologia >Memory signals from the thalamus: Early thalamocortical phase synchronization entrains gamma oscillations during long-term memory retrieval
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Memory signals from the thalamus: Early thalamocortical phase synchronization entrains gamma oscillations during long-term memory retrieval

机译：丘脑的记忆信号：早期丘脑皮质相位同步会在长期记忆检索期间夹带伽马振荡

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摘要

The thalamus is believed to be a key node in human memory networks, however, very little is known about its real-time functional role. Here we examined the dynamics of thalamocortical communication during long-term episodic memory retrieval in two experiments. In Experiment 1, intrathalamic and surface EEG was recorded in an epileptic patient implanted with depth electrodes for brain stimulation therapy. In a recognition memory test, early (300-500. ms) stimulus-linked oscillatory synchrony between mediodorsal thalamic and frontal surface electrodes at beta frequency (20. Hz) was enhanced for correctly remembered old compared to correctly rejected new items. Directionality measures (Granger causality) indicated that the thalamus was the sender, and the neocortex the receiver, of this beta signal, which also modulated the power of neocortical gamma (55-80. Hz) oscillations (cross-frequency coupling). Experiment 2 validated the cross-frequency coupling effects in a healthy participant sample. Confirming the findings from Experiment 1, significantly increased cross-frequency coupling was found over frontal scalp electrodes during successful recognition. Extending anatomical knowledge on thalamic connectivity with frontal neocortex, these results suggest that the thalamus sends an early memory signal to frontal regions, triggering further memory search processes.
机译：丘脑被认为是人类记忆网络中的关键节点，然而，对其实时功能的作用知之甚少。在这里，我们在两个实验中研究了长期情景记忆检索期间丘脑皮质通讯的动力学。在实验1中，在植入深度电极进行脑刺激治疗的癫痫患者中记录了丘脑内和表面EEG。在识别记忆测试中，增强了对中嗅丘脑和额叶表面电极在β频率（20 Hz）处的早期（300-500。ms）刺激相关的振荡同步性，与正确剔除的新项目相比，正确记住的旧项目得到了增强。方向性度量（Granger因果关系）表明，丘脑是该beta信号的发送者，而新皮质则是该β信号的接收者，它还调制了新皮层伽马（55-80。Hz）振荡（跨频耦合）的功率。实验2验证了健康参与者样本中的交叉频率耦合效应。确认实验1的发现，在成功识别过程中，额叶头皮电极上的交叉频率耦合显着增加。这些结果扩展了丘脑与额叶新皮质的连接的解剖学知识，表明丘脑向额叶区域发送了早期记忆信号，从而触发了进一步的记忆搜索过程。

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