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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Expression of the p75 neurotrophin receptor by striatal cholinergic neurons following global ischemia in rats is associated with neuronal degeneration.
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Expression of the p75 neurotrophin receptor by striatal cholinergic neurons following global ischemia in rats is associated with neuronal degeneration.

机译：大鼠整体缺血后，纹状体胆碱能神经元表达p75神经营养因子受体与神经元变性有关。

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摘要

The induction of the p75 neurotrophin receptor (p75NTR) on striatal cholinergic neurons by global hypoxic-ischemia has been reported to promote neuron survival. We have found, however, while the p75NTR-expressing neurons survive the insult for the first 5 days, subsequently they undergo shrinkage, loss of choline acetyl transferase (ChAT) expression, and more than 96% are eventually lost by 8 days. In contrast ChAT-expressing cells in the surrounding region of the infarction, do not express p75NTR and there is no evidence of neuronal loss. These results suggest the expression of p75NTR on cholinergic interneurons of the rat striatum is associated with delayed neuronal degeneration.
机译：据报道，全球缺氧缺血在纹状体胆碱能神经元上诱导p75神经营养素受体（p75NTR）可以促进神经元的存活。然而，我们发现，尽管表达p75NTR的神经元在最初的5天中都幸免于难，但随后它们发生了收缩，胆碱乙酰转移酶（ChAT）表达丧失，并在8天之内最终损失了96％以上。相反，在梗塞周围区域中表达ChAT的细胞不表达p75NTR，也没有神经元丢失的证据。这些结果表明在大鼠纹状体的胆碱能中间神经元上p75NTR的表达与延迟的神经元变性有关。

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