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首页> 外文期刊>Materials science & engineering, C. Materials for Biogical applications >Biocompatible lutein-polymer-lipid nanocapsules: Acute and subacute toxicity and bioavailability in mice
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Biocompatible lutein-polymer-lipid nanocapsules: Acute and subacute toxicity and bioavailability in mice

机译：生物相容性叶黄素-聚合物-脂质纳米胶囊：小鼠的急性和亚急性毒性和生物利用度

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Lutein-poly-(lactic-co-glycolic acid) (PLGA)-phospholipid (PL) nanocapsules were prepared (henceforth referred as lutein nanocapsules) and studied for acute, subacute oral toxicity and bioavailability of lutein in mice. Prior to examining the safety of lutein nanocapsules, particle size, zeta potential, surface morphology and interaction between lutein, PLGA and PL were studied. In acute study, mice were gavaged with a single dose of lutein nanocapsules at 0.1, 1, 10 and 100 mg/kg body weight (BW) and examined for 2 weeks, while in subacute study, daily mice were gavaged with a dose of 1 and 10 mg/kg BW for 4 weeks. Results revealed that mean size and zeta value of lutein nanocapsules were 140 nm and -44 mV, respectively. Acute and subacute toxicity studies did not show any mortality or treatment related adverse effect in clinical observations, ophthalmic examinations, body and organ weights. No toxicity related findings were observed in hematology, histopathology and other blood and tissue clinical chemistry parameters. In subacute study, no observed adverse effect level (NOAEL) of lutein nanocapsules was found to be at a dose of 10 mg/kg BW. Feeding lutein nanocapsules resulted in a significant (p < 0.01) increase in lutein level in plasma and tissue compared to the control group. Lutein nanocapsules did not cause toxicity in mice. However, human-trials are warranted. (C) 2016 Elsevier B.V. All rights reserved.
机译：制备叶黄素聚（乳酸-乙醇酸共聚物）（PLGA）-磷脂（PL）纳米胶囊（以下称为叶黄素纳米胶囊）并研究叶黄素在小鼠中的急性，亚急性口服毒性和生物利用度。在检查叶黄素纳米胶囊的安全性之前，研究了叶黄素，PLGA和PL之间的粒径，ζ电位，表面形态以及相互作用。在急性研究中，以0.1、1、10和100 mg / kg体重（BW）的单剂量叶黄素纳米胶囊对小鼠进行管饲，并检查2周;而在亚急性研究中，每天以1剂量对小鼠进行管饲。和10 mg / kg BW持续4周。结果表明，叶黄素纳米胶囊的平均大小和Zeta值分别为140 nm和-44 mV。急性和亚急性毒性研究在临床观察，眼科检查，体重和器官重量方面均未显示任何死亡率或与治疗相关的不良反应。在血液学，组织病理学以及其他血液和组织临床化学参数中未观察到与毒性相关的发现。在亚急性研究中，未发现叶黄素纳米胶囊的不良反应水平（NOAEL）为10 mg / kg BW。与对照组相比，饲喂叶黄素纳米胶囊会导致血浆和组织中叶黄素水平显着提高（p <0.01）。叶黄素纳米胶囊对小鼠没有毒性。但是，必须进行人工试验。 （C）2016 Elsevier B.V.保留所有权利。

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