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首页> 外文期刊>New Journal of Chemistry >Influence of morphology on the in vitro bioactivity of hydroxyapatite nanostructures prepared by precipitation method
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Influence of morphology on the in vitro bioactivity of hydroxyapatite nanostructures prepared by precipitation method

机译：形态对沉淀法制备羟基磷灰石纳米结构体外生物活性的影响

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摘要

It seems that the available studies about the effect of morphology on the bioactivity of pure hydroxyapatite (Ca_(10)(PO4)6(OH)2, HAP) are yet insufficient. For this purpose, a novel morphology-controlled synthesis method to fabricate HAP nanostructures is employed by using different Schiff bases as chelating ligands. The formation mechanism of zero-dimensional (0-D) and one-dimensional (1-D) nanostructures of HAP is also considered. Based on the morphological studies of the final products, it is found that the formation of tetradentate and bidentate ligands leads to the preparation of 0-D and 1-D HAP nanocrystals, respectively. The in vitro bioactivity of the as-produced HAP nanostructures is evaluated by soaking the products in simulated body fluid (SBF). The analytical measurements indicate that the changes in the Ca and P concentrations of the 1-D HAP nanostructures are more than those of the 0-D HAP nanostructures, indicating good bioactivity of the nanorpds and nanobundles. The formation of new apatite crystals on the surfaces of the HAP nanostructures soaked in the SBF solutions is proved by field emission scanning electron microscopy (FESEM) and diffuse reflectance Fourier transform infrared spectrometry (ATR-FTIR).
机译：似乎有关形态对纯羟基磷灰石（Ca_（10）（PO4）6（OH）2，HAP）生物活性的影响的可用研究尚不充分。为了这个目的，通过使用不同的席夫碱作为螯合配体，采用新颖的形态学控制的合成方法来制造HAP纳米结构。还考虑了HAP的零维（0-D）和一维（1-D）纳米结构的形成机理。根据最终产物的形态学研究，发现四齿和双齿配体的形成分别导致了0-D和1-D HAP纳米晶体的制备。通过将产品浸泡在模拟体液（SBF）中来评估所产生的HAP纳米结构的体外生物活性。分析测量结果表明，一维HAP纳米结构的Ca和P浓度的变化大于0维HAP纳米结构的变化，表明nanorpds和纳米束具有良好的生物活性。通过场发射扫描电子显微镜（FESEM）和漫反射傅里叶变换红外光谱（ATR-FTIR）证明了SBF溶液中浸泡的HAP纳米结构表面上新的磷灰石晶体的形成。

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