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首页> 外文期刊>New Journal of Chemistry >The shape effect of mesoporous silica nanoparticles on intracellular reactive oxygen species in A375 cells
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The shape effect of mesoporous silica nanoparticles on intracellular reactive oxygen species in A375 cells

机译：介孔二氧化硅纳米颗粒对A375细胞内细胞内活性氧形态的影响

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摘要

Mesoporous silica nanoparticles (MSNs) have attracted great attention in various biomedical applications. However, a detailed mechanism of intracellular behavior, such as reactive oxygen species (ROS), induced by MSNs, has been still paid little consideration to date. In this study, we first found that MSNs with different aspect ratios (1, 2, and 4) could decrease the intracellular ROS level in serum-free media, whereas the introduction of serum proteins could upregulate and display shape-dependent behavior. The ROS regulation mechanism by particle shapes in A375 cells was then analyzed by examining the endocytosis amount of MSNs, the mitochondrial damage, and the ROS-scavenging ability. These results indicated that the particle shapes play significant roles in regulating endogenous ROS. We envisage that the complete oxidative stress study of different shaped MSNs would provide important guidelines when considering the overall toxicity of these nanocarriers in biomedical applications.
机译：介孔二氧化硅纳米颗粒（MSN）在各种生物医学应用中引起了极大的关注。但是，迄今为止，仍很少考虑到由MSN诱导的细胞内行为的详细机制，例如活性氧（ROS）。在这项研究中，我们首先发现具有不同长宽比（1、2和4）的MSN可以降低无血清培养基中的细胞内ROS水平，而引入血清蛋白可以上调并显示形状依赖性行为。然后通过检查MSN的内吞作用量，线粒体损伤和清除ROS的能力，分析了A375细胞中颗粒形状对ROS的调节机制。这些结果表明，颗粒形状在调节内源性ROS中起重要作用。我们设想，当考虑这些纳米载体在生物医学应用中的总体毒性时，对不同形状的MSN进行完整的氧化应激研究将提供重要的指导。

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