• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>journal of clinical and diagnostic research >Hyperpigmentation Induced by Hydroxychloroquine: A Case Report
【24h】

Hyperpigmentation Induced by Hydroxychloroquine: A Case Report

机译：

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hydroxychloroquine is an antimalarial drug which is widely used in the treatment of rheumatoid arthritis, owing to its immunosuppressive and anti-inflammatory properties. Mucocutaneous hyperpigmentation induced by hydroxychloroquine is rarely reported. The time temporal relationship between the starting of hydroxychloroquine therapy and the onset of hyperpigmentation of the skin ranges from three months to 22 years. This report presents a case of 48-year-old female with rheumatoid arthritis who developed hyperpigmentation on the face and skin during the treatment with hydroxychloroquine. She was treated with hydroxychloroquine for one year. Hyperpigmentation on the face and skin started after nine months of initiation of hydroxychloroquine therapy and skin biopsy showed skin with epidermis displaying increased basal melanin. The superficial dermis showed increased collagenisation. Perls stain was done, which did not stain the pigment. This presentation of melanin deposition alone is rare as previous reports of hyperpigmentation indicate the presence of both melanin and haemosiderin in patients being treated with antimalarial medication. The patient was advised to stop hydroxychloroquine and as an alternate drug, methotrexate 7.5 mg (two times per week) was started for her. Stoppage of hydroxychloroquine resulted in the decline of the pigmentation over the course of several months.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号