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首页> 外文期刊>New Journal of Chemistry >Preparation of a high specific surface area monolithic silica reversed phase chromatography column using a template induced method
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Preparation of a high specific surface area monolithic silica reversed phase chromatography column using a template induced method

机译：利用模板诱导法制备高比表面积的整体硅胶反相色谱柱

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In this study we report a new method for the synthesis of a silica monolithic reverse phase chromatography column. Instead of the usual base corrosion method a template induced synthesis method was used to create bimodal pores in the column bed. Block polymer Pluronic F127 was used as a dual-function template to form a hierarchically porous silica monolith with both macropores and mesopores. Poly(ethylene glycol) was used in combination with F127 to effectively control the mesopore size distribution and the volume shrinkage during the gelation step. The resultant material showed a much narrower mesopore size distribution (centered at 6 nm) than that using F127 as the only template reagent. The surface of the silica monolithic column bed was modified in situ by the C18 reagent, and was then evaluated by a μ-HPLC method. A large number of theoretical plates were observed (>110 000/m) indicating that the new synthesis method creates a monolithic material that can act as a chromatographically efficient stationary phase. The method also makes the fabrication of the silica monolithic column (especially capillary columns) much simpler.
机译：在这项研究中，我们报告了一种合成硅胶整体反相色谱柱的新方法。代替通常的基础腐蚀方法，使用模板诱导的合成方法在柱床中创建双峰孔。嵌段聚合物Pluronic F127用作双功能模板，以形成具有大孔和中孔的分层多孔二氧化硅整体。聚乙二醇与F127结合使用，可有效控制胶凝步骤中的中孔尺寸分布和体积收缩。与使用F127作为唯一模板试剂的结果相比，所得材料显示出的中孔尺寸分布（中心在6 nm）要窄得多。二氧化硅整体柱床的表面用C18试剂原位修饰，然后通过μ-HPLC方法进行评估。观察到大量理论塔板数（> 110000 / m），表明新的合成方法可形成可作为色谱有效固定相的整体材料。该方法还使二氧化硅整体柱（特别是毛细管柱）的制造更加简单。

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