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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >Cytomorphometric changes in rat brain neurons after rapid eye movement sleep deprivation.
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Cytomorphometric changes in rat brain neurons after rapid eye movement sleep deprivation.

机译：快速眼动睡眠剥夺后大鼠脑神经元的细胞形态变化。

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摘要

Rapid eye movement sleep plays a vital role in the survival of animals. Its deprivation causes alterations in brain functions and behaviors including activities of important enzymes, neurotransmitter levels, impairment of neural excitability and memory consolidation. However, there was a lack of knowledge regarding the effects of rapid eye movement sleep deprivation on neuronal morphology that may get affected much earlier than any permanent damage to the neurons. In the present study, some of these issues have been addressed by studying the effects of rapid eye movement sleep deprivation on various morphological parameters viz. neuronal perimeter, area and shape of neurons located in brain areas known to regulate rapid eye movement sleep and as a control in other brain areas which do not regulate rapid eye movement sleep. The results showed that rapid eye movement sleep deprivation differentially affected neurons depending on their physiological correlates of rapid eye movement sleep and neurotransmitter content. The effects could be reversed if the animals were allowed to recover from rapid eye movement sleep loss or by applying alpha1-adrenergic antagonist, prazosin. The findings in rats support reported data and help explaining previous observations.
机译：快速的眼球运动睡眠对动物的生存至关重要。它的剥夺导致大脑功能和行为的改变，包括重要酶的活性，神经递质水平，神经兴奋性受损和记忆巩固。然而，缺乏关于快速眼动睡眠剥夺对神经元形态的影响的知识，神经元形态可能比对神经元的任何永久性损害要早得多。在本研究中，其中一些问题已通过研究快速眼动睡眠剥夺对各种形态学参数的影响来解决。位于已知调节快速眼动睡眠的大脑区域的神经元的神经元周长，面积和形状，并作为不调节快速眼动睡眠的其他大脑区域的对照。结果表明，快速眼动睡眠剥夺对神经元的影响不同，这取决于它们与快速眼动睡眠和神经递质含量的生理相关性。如果允许动物从快速的眼球运动睡眠丧失中恢复过来，或者通过应用α1-肾上腺素能拮抗剂哌唑嗪可以恢复这种作用。大鼠的发现支持报道的数据，并有助于解释先前的观察结果。

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