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首页> 外文期刊>Neuroscience Research: The Official Journal of the Japan Neuroscience Society >Prenatal nicotine exposure increases anxiety and modifies sensorimotor integration behaviors in adult female mice
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Prenatal nicotine exposure increases anxiety and modifies sensorimotor integration behaviors in adult female mice

机译：产前尼古丁暴露会增加成年雌性小鼠的焦虑感并改变其感觉运动整合行为

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摘要

Prenatal exposure to nicotine (PNE) has been associated with a myriad of physiological, cognitive, and behavioral effects in the developing offspring. In this study, CD-1 dams were given injections of nicotine or control vehicle throughout gestation and their offspring were raised to 6 months of age. Adult mice were administered a battery of behavioral tests (the Suok test, the elevated platform test, and the elevated plus maze test) to assess anxiety and sensorimotor integration. PNE resulted in a decreased likelihood of jumping during the elevated platform test and decreased directed exploration in the Suok test, both indicative of increased anxiety. Also, PNE mice showed increased numbers of missteps while traversing an elevated rod in the Suok test, demonstrating altered sensorimotor integration. No significant differences were found in falls, segments traveled, latency to leave the central zone, vegetative responses, risk assessment behaviors, or autogroom behaviors. The elevated plus maze test revealed no significant differences between groups. No significant differences in body and brain weights, or cortical thickness within motor, somatosensory, and visual cortices were observed between PNE and control mice. Although neuroanatomical effects of PNE may be rescued as development progresses, defects in sensorimotor integration and increased anxiety persist into adulthood.
机译：产前暴露于尼古丁（PNE）已与发育中的后代产生多种生理，认知和行为影响。在这项研究中，在整个妊娠期间给CD-1大坝注射尼古丁或对照载体，并将它们的后代长到6个月大。对成年小鼠进行一系列行为测试（Suok测试，高架平台测试和高架迷宫测试），以评估焦虑和感觉运动整合。 PNE导致在升高的平台测试期间跳跃的可能性降低，而在Suok测试中导致的定向探查减少，这两者均表明焦虑加剧。同样，PNE小鼠在Suok测试中横穿升高的杆时显示出错误的步伐次数增加，表明感觉运动整合发生了改变。在跌倒，行进的路段，离开中心区域的潜伏时间，植物反应，风险评估行为或自动修饰行为方面，没有发现显着差异。高架迷宫测试显示两组之间无显着差异。在PNE和对照小鼠之间，未观察到体重和大脑重量或运动，体感和视觉皮层内皮质厚度的显着差异。尽管随着发展的进展，PNE的神经解剖学作用可以挽救，但感觉运动整合缺陷和焦虑加剧仍持续到成年期。

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