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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >Acute effects of sublingual buprenorphine on brain responses to heroin-related cues in early-abstinent heroin addicts: an uncontrolled trial.
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Acute effects of sublingual buprenorphine on brain responses to heroin-related cues in early-abstinent heroin addicts: an uncontrolled trial.

机译：舌下丁丙诺啡对早期戒断海洛因依赖者大脑对海洛因相关线索的大脑反应的急性影响：一项无对照试验。

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Replacement therapy with buprenorphine is clinically effective in reducing withdrawal and craving for heroin during detoxification but not in decreasing the probability of relapse after detoxification. This study examined the acute effects of buprenorphine on brain responses to heroin-related cues to reveal the neurobiological and therapeutic mechanisms of addiction and relapse. Fifteen heroin addicts at a very early period of abstinence, were studied in two separate periods 10-15 min apart: an early period (5-45 min) and a later period (60-105 min) after sublingual buprenorphine, roughly covering the onset and peak of buprenorphine plasma level. During both periods, fMRI scanning with heroin-related visual stimuli were performed followed by questionnaires. Under effect of buprenorphine, brain responses to heroin-related cues showed decrease in amygdala, hippocampus, ventral tegmental area (VTA) and thalamus but no changes in ventral striatum and orbital-prefrontal-parietal cortices. As an uncontrolled trial, these preliminary results suggest that buprenorphine has specific brain targets in reducing withdrawal and craving during early abstinence, and that ventral striatum and orbital-prefrontal-parietal cortices may be the key targets in developing therapy for drug addiction and relapse.
机译：丁丙诺啡替代疗法在减少排毒过程中对海洛因的戒断和渴望方面具有临床效果，但在减少排毒后复发的可能性方面没有临床效果。这项研究检查了丁丙诺啡对脑对海洛因相关线索的反应的急性作用，以揭示成瘾和复发的神经生物学和治疗机制。在禁欲的非常早期阶段，对15个海洛因成瘾者进行了研究，分别在相距10-15分钟的两个不同时期进行：舌下丁丙诺啡后的早期（5-45分钟）和后期（60-105分钟），大致涵盖了发病时间和丁丙诺啡血浆水平的峰值。在这两个时期，均进行了海洛因相关视觉刺激的功能磁共振成像扫描，随后进行了问卷调查。在丁丙诺啡的作用下，大脑对海洛因相关提示的反应显示杏仁核，海马，腹侧被盖区（VTA）和丘脑减少，但腹侧纹状体和眶前额叶顶皮质没有变化。作为一项未经控制的试验，这些初步结果表明，丁丙诺啡具有特定的大脑靶点，可以减少早期禁欲期间的戒断和渴望，腹侧纹状体和眶前额叶顶皮质可能是开发药物成瘾和复发的关键靶标。

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