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首页> 外文期刊>Neurosurgery >Intratumoral arteriovenous shunting in malignant gliomas.
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Intratumoral arteriovenous shunting in malignant gliomas.

机译：恶性神经胶质瘤的瘤内动静脉分流。

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OBJECTIVE: Intratumoral arteriovenous shunting in glioblastomas has been suspected but neither proven nor quantified. METHODS: Using a previously described technique of selective intra-arterial intratumoral injection of 99mTc-labeled microparticles (macroaggregated albumin), we measured the amount of radioactivity, by cerebral and pulmonary scintigraphy, in seven patients with malignant gliomas (six with glioblastomas and one with an anaplastic oligodendroglioma). The pulmonary shunt index was calculated as a percentage from the pulmonary/pulmonary plus cerebral radioactivity ratio. RESULTS: The results revealed a mean pulmonary shunt index of 67% (range, 47-89%), indicating that most of the microparticles injected into the tumor via the arterial route bypassed the tumor and reached the lungs. The measured arteriovenous shunting was greater when the injection was performed in an artery exclusively perfusing the tumor. CONCLUSION: Important intratumoral arteriovenous shunting exists in glioblastomas. The potential consequences of this finding for intra-arterial treatment strategies are discussed.
机译：目的：已经怀疑胶质母细胞瘤的瘤内动静脉分流，但未得到证实或量化。方法：使用先前描述的选择性动脉内瘤内注射99mTc标记的微粒（宏观聚集白蛋白）的技术，我们通过脑和肺闪烁显像技术测量了7例恶性神经胶质瘤（6例胶质母细胞瘤和1例胶质母细胞瘤）的放射性水平。间变性少突胶质细胞瘤）。肺分流指数是根据肺/肺与脑部放射性之比计算得出的百分比。结果：结果显示平均肺分流指数为67％（范围47-89％），表明大多数通过动脉途径注入肿瘤的微粒绕过了肿瘤并到达了肺部。当在仅灌注肿瘤的动脉中进行注射时，测得的动静脉分流更大。结论：胶质母细胞瘤中存在重要的肿瘤内动静脉分流。讨论了这一发现对动脉内治疗策略的潜在后果。

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