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首页> 外文期刊>Neurosurgery >The natural history of incidental meningiomas.
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The natural history of incidental meningiomas.

机译：偶然性脑膜瘤的自然病史。

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OBJECTIVE: Little information about the natural history of incidental meningiomas exists in the literature. The aim of this study was to determine the natural history of asymptomatic meningiomas by comparing different methods of growth rate calculation to establish a strategy for dealing with these tumors. METHODS: In 47 asymptomatic patients, hospital charts, follow-up records, and imaging studies were reviewed. Of these patients, 6 underwent surgery. Tumor growth rates were determined by calculating the absolute and relative growth rates and the tumor volume doubling times. RESULTS: In 41 patients with conservative management, the average tumor size was 9 cm(3), and the majority (66%) of growth rates were less than 1 cm(3)/yr. The absolute growth rate ranged from 0.03 to 2.62 cm(3)/yr (mean, 0.796 cm(3)/yr). Relative annual growth rates ranged from 0.48 to 72.8% (mean, 14.6%). The tumor doubling time ranged from 1.27 to 143.5 years (mean, 21.6 yr). A moderate correlation between the age and growth rates was found. In young patients, annual growth rates tended to be higher and tumor doubling times shorter. There was no clear correlation between the initial tumor size and tumor doubling time. The mean annual growth rate of meningiomas with calcification was lower than in tumors without calcification. Also, tumors with hypointense or isointense T2 signals on magnetic resonance imaging had a lower growth rate. In the group of six patients with surgical excision, tumor growth rates were higher and tumor doubling times shorter than in the nonsurgical group. CONCLUSION: The majority of incidental meningiomas show minimal growth; thus, they may be observed without surgical intervention unless specific symptoms appear. Tumor growth is associated with patient age. The initial tumor size is not considered a predictive factor for tumor growth. Radiological features, such as calcification or T2 signal intensity, may provide useful information to predict the growth potential of meningiomas.
机译：目的：关于偶发性脑膜瘤自然病史的文献很少。这项研究的目的是通过比较不同的增长率计算方法来确定无症状性脑膜瘤的自然病史，以建立应对这些肿瘤的策略。方法：对47名无症状患者进行了病历，随访记录和影像学检查。这些患者中，有6人接受了手术。通过计算绝对和相对生长速率以及肿瘤体积加倍时间来确定肿瘤生长速率。结果：41例保守治疗的患者，平均肿瘤大小为9 cm（3），大多数（66％）的生长率低于1 cm（3）/ yr。绝对增长率为0.03至2.62 cm（3）/年（平均0.796 cm（3）/年）。相对年增长率在0.48至72.8％之间（平均14.6％）。肿瘤加倍时间为1.27至143.5年（平均21.6年）。发现年龄和增长率之间存在中等相关性。在年轻患者中，年增长率趋于较高，而肿瘤倍增时间较短。初始肿瘤大小和肿瘤倍增时间之间没有明确的相关性。有钙化的脑膜瘤的年平均增长率低于没有钙化的肿瘤。同样，在磁共振成像上具有低信号或等强度T2信号的肿瘤具有较低的生长速率。与非手术组相比，在六例接受手术切除的患者中，肿瘤的生长速率更高，肿瘤倍增时间更短。结论：大多数偶发性脑膜瘤生长最小。因此，除非出现特定症状，否则无需手术干预即可观察到它们。肿瘤生长与患者年龄有关。最初的肿瘤大小不被认为是肿瘤生长的预测因素。放射学特征，例如钙化或T2信号强度，可提供有用的信息来预测脑膜瘤的生长潜力。

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