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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >Role of central cholinergic receptor sub-types in spatial working memory: a five-arm maze task in mice provides evidence for a functional role of nicotinic receptors in mediating trace access processes.
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Role of central cholinergic receptor sub-types in spatial working memory: a five-arm maze task in mice provides evidence for a functional role of nicotinic receptors in mediating trace access processes.

机译：中枢胆碱能受体亚型在空间工作记忆中的作用：在小鼠中进行的五臂迷宫任务为烟碱样受体在介导痕量进入过程中的功能性作用提供了证据。

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A delayed-matching spatial working memory protocol in a 5-arm maze was used to test the hypothesis of differential roles for central nicotinic and muscarinic cholinergic receptors in mediating task performance. In experiment 1, using a within subjects-repeated design, groups of C57Bl/6 mice, previously trained to criterion with a 4 h retention interval separating presentation and test phases, received i.p. injections of either saline, scopolamine (0.8 mg/kg), mecamylamine (8.0 mg/kg), or the combination of scopolamine and mecamylamine before re-testing. Injections were given either, a) 15 min pre-presentation or, b) 30 s, c) 15 min, d) 3 h 45 min post-presentation in order to differentially affect the acquisition, trace maintenance and recall phases. Significant decreases in correct responses were observed for each drug treatment but the effects were a function of the time of treatment. Results of condition d), (i.e.15 min before retention test) confirm previous reports of severe disruption by each antagonist and their combination on retention. However, conditions a-c) show a constant disruption by scopolamine, increasing disruption by mecamylamine, whereas the combined treatment was without effect. Although the data show that central nicotinic and muscarinic antagonists both modulate working memory performance, they indicate first, that scopolamine-induced "amnesia" results, not from selective post-synaptic M1 muscarinic blockade but from indirect over-activation of nicotinic receptors. Second, the observation of high levels of retention although nicotinic and muscarinic receptors had undergone combined blockade during a large part of the retention interval is incompatible with the concept that test-induced activation of central cholinergic neurones mediates memory trace maintenance. Finally, taken with data from experiment 2, using a short (20 min) treatment-to-test interval, we conclude that central nicotinic receptors play a key role in attentional processes enabling working memory trace access during retrieval.
机译：在5臂迷宫中使用延迟匹配的空间工作记忆协议，以检验中枢烟碱和毒蕈碱胆碱能受体在介导任务执行中的不同作用的假设。在实验1中，采用受试者重复设计，预先经训练以4 h保留间隔将呈递阶段和测试阶段分开的C57Bl / 6小鼠组接受腹腔注射。在重新测试之前，先注射生理盐水，东pol碱（0.8 mg / kg），美卡敏（8.0 mg / kg）或东and碱和美卡敏的组合。注射后a）演示前15分钟或b）30 s，c）15分钟，d）演示后3 h 45 min，以差异地影响采集，跟踪维护和召回阶段。每种药物治疗均观察到正确反应的显着降低，但效果是治疗时间的函数。条件d）的结果（即保留试验前15分钟）证实了先前报道的每种拮抗剂及其结合对保留的严重破坏作用。然而，条件a-c）显示出东碱的恒定破坏，增加了美甲胺的破坏，而联合治疗无效。尽管数据表明中枢烟碱和毒蕈碱拮抗剂均能调节工作记忆性能，但它们首先表明，东pol碱诱导的“健忘症”不是由选择性的突触后M1毒蕈碱封锁引起的，而是由烟碱样受体的间接过度活化引起的。其次，尽管在大部分保留间隔中烟碱和毒蕈碱受体都经历了联合阻滞，但仍观察到高水平的保留，这与测试诱导的中枢胆碱能神经元激活介导记忆痕迹维持的概念不符。最后，从实验2获得的数据（使用较短（20分钟）的治疗至测试间隔）得出的结论是，中枢烟碱样受体在注意过程中起着关键作用，从而在检索过程中实现了对工作记忆的跟踪访问。

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