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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >Changes in brain cholecystokinin and anxiety-like behavior following exposure of mice to predator odor.
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Changes in brain cholecystokinin and anxiety-like behavior following exposure of mice to predator odor.

机译：小鼠暴露于捕食者气味后脑胆囊收缩素和焦虑样行为的变化。

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摘要

Exposure of CD-1 mice to a familiar environment lined with clean shavings (control odor) as well as a familiar environment lined with soiled rat shavings (predator odor) induced anxiety in the light/dark box. Mice exposed to the familiar environment or predator odor displayed decreased latency to enter the dark chamber of the light/dark box and spent less time in the light portion of the apparatus relative to home-caged mice. Mice exposed to the familiar environment lined with clean shavings or predator odor displayed elevated cholecystokinin mRNA levels from the ventral tegmental area, medial and basolateral nuclei of the amygdala relative to home-caged mice. Exposure of CD-1 mice to 2, 5 or 10 min of predator odor increased acoustic startle relative to mice merely exposed to the familiar environment lined with clean shavings at protracted intervals. Mice exposed to the familiar environment lined with clean shavings did not exhibit enhanced startle relative to home-caged mice. Exaggerated startle reactivity was in evidence immediately, 24, and 48 h following a 5-min exposure of mice to predator odor. In contrast, a 10-min exposure of mice to predator odor produced an oscillating pattern of enhanced startle evident during the immediate and 48-h post-stressor intervals only. However, when the startle stimulus was withheld 1 h following odor presentation, mice exhibited enhanced startle patterns reminiscent of the 5-min exposure. The 2-min exposure of mice to predator odor produced a delayed onset of enhanced startle observed at the 168-h test interval only. Potential anxiogenic influences of mesocorticolimbic cholecystokinin availability as well as the time course and underlying neuronal substrates of long-term behavioral disturbances as a result of psychogenic stressor manipulations are discussed.
机译：将CD-1小鼠暴露于衬有干净刨花（控制气味）的熟悉环境以及衬有脏老鼠切屑（捕食者气味）的熟悉环境，会在明/暗盒子中引起焦虑。暴露于熟悉环境或捕食者气味的小鼠相对于笼养小鼠而言，进入亮/暗盒暗室的潜伏期缩短，并且在设备的亮部花费的时间更少。暴露于熟悉的环境中的小鼠衬有干净的刨花或捕食者的气味，相对于笼养小鼠而言，杏仁核腹侧被盖区，内侧和基底外侧核的胆囊收缩素mRNA水平升高。相对于仅暴露于熟悉的环境中且间隔较长的干净刨花的小鼠，将CD-1小鼠暴露于2、5、10分钟的捕食者气味会增加听觉惊吓。暴露于熟悉的环境中并贴有干净刨花的小鼠相对于笼养小鼠没有表现出增强的惊吓。在小鼠暴露于食肉动物气味5分钟后立即，24和48小时，发现惊恐反应过度。相比之下，将小鼠暴露于捕食者气味中10分钟会在震后立即间隔和48小时间隔内产生明显增强的惊吓振荡模式。但是，当气味出现后1小时停止惊吓刺激时，小鼠表现出增强的惊吓模式，使人想起5分钟的暴露。仅在168小时的测试时间间隔内，小鼠暴露于捕食者气味中2分钟后，惊吓的发作才有所延迟。讨论了中皮层皮质胆囊收缩素可用性的潜在焦虑作用，以及由于心理压力源操纵导致的长期行为障碍的时间进程和潜在的神经元底物。

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