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首页> 外文期刊>Neurosurgery >Expressive and receptive language areas determined by a non-invasive reliable method using functional magnetic resonance imaging and magnetoencephalography.
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Expressive and receptive language areas determined by a non-invasive reliable method using functional magnetic resonance imaging and magnetoencephalography.

机译：通过使用功能性磁共振成像和脑磁图检查的非侵入性可靠方法确定的表达和接受语言区域。

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OBJECTIVE: It is known that functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) are sensitive to the frontal and temporal language function, respectively. Therefore, we established combined use of fMRI and MEG to make reliable identification of the global language dominance in pathological brain conditions. METHODS: We investigated 117 patients with brain lesions whose language dominance was successfully confirmed by the Wada test. All patients were asked to generate verbs related to acoustically presented nouns (verb generation) for fMRI and to read three-letter words for fMRI and MEG. RESULTS: fMRI typically showed prominent activations in the inferior and middle frontal gyri, whereas calculated dipoles on MEG typically clustered in the superior temporal region and the fusiform gyrus of the dominant hemisphere. A total of 87 patients were further analyzed using useful data from both the combined method and the Wada test. Remarkably, we observed a 100% match of the combined method results with the results of the Wada test, including two patients who showed expressive and receptive language areas dissociated into bilateral hemispheres. CONCLUSION: The results demonstrate that this non-invasive and repeatable method is not only highly reliable in determining language dominance, but can also locate the expressive and receptive language areas separately. The method may be a potent alternative to invasive procedures of the Wada test and useful in treating patients with brain lesions.
机译：目的：已知功能磁共振成像（fMRI）和脑磁图（MEG）分别对额叶和颞叶语言功能敏感。因此，我们建立了功能磁共振成像和MEG的结合使用，以可靠地识别病理性脑病中的全球语言优势。方法：我们调查了117例脑损伤的患者，他们的语言优势已通过Wada检验成功确认。所有患者均被要求为功能磁共振成像产生与声学上呈现的名词相关的动词（动词产生），并为功能磁共振成像和MEG朗读三个字母的单词。结果：功能磁共振成像通常显示在下额中回和前额回中的显着激活，而在MEG上计算出的偶极子通常聚集在颞上叶和优势半球的梭状回中。使用来自组合方法和Wada检验的有用数据对总共87例患者进行了进一步分析。值得注意的是，我们观察到组合方法的结果与Wada测试的结果100％匹配，包括两名表现出表达能力和接受能力的语言区域分离到双侧半球的患者。结论：结果表明，这种非侵入性和可重复的方法不仅在确定语言优势方面是高度可靠的，而且可以分别定位表达性和接受性语言区域。该方法可能是Wada试验的有创方法的有效替代方法，可用于治疗脑部病变患者。

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