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首页> 外文期刊>Neurosurgery >Dual Microelectrode Technique for Deep Brain Stereotactic Surgery in Humans
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Dual Microelectrode Technique for Deep Brain Stereotactic Surgery in Humans

机译：双微电极技术在人类深部脑立体定向手术中的应用

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OBJECTIVE: To improve functional slereotaclic microeleclrode localization of small deep brain structures by developing and evaluating a recording system with two closely separated independently controlled ink roelectrodes. METHODS: Data were obtained from 52 patients using this dual microelectrode technique and 38 patients using the standard single microelectrode technique lor subthal-amic nucleus localization in patients with Parkinson's disease. RESULTS:There was a decrease in the incidence of nonconlributory trajectories, defined as a single penetration made by the pair of closely spaced parallel microelectrodes, owing to microeleclrode failure ifrom 7.2% to <1%), an improved localization and verification of nuclear borders, and a significant decrease in the number of trajectories used to localize the subthulamk nucleus from a median of three to two per initial operative side(P < 0.001 ). The technique also provides the novel opportunity to examine population activity by correlating the discharge between two closely spaced simultaneously recorded neurons and can be used to monitor the elcctrophysiologkal effects of local electrical stimulation or microinjections of pharmacological agents. CONCLUSION: Our experience indicates that the use of two closely spaced micro-electrodes improves the utility of microeleclrode localization in minimally invasive functional neurosurgery.
机译：目的：通过开发和评估具有两个紧密分开的独立控制的墨电极的记录系统，改善小深部大脑结构的功能性硬脑膜微电极定位。方法：使用双微电极技术从52例患者和使用标准单微电极技术或丘脑下丘脑核定位的38例患者中获取了帕金森病患者的数据。结果：非共线轨迹的发生率有所下降，这是由于一对紧密间隔的平行微电极对单极穿透的影响（由于IF％7.2％到<1％）导致的微电极失效，核边界的定位和验证得到了改善，并且用于定位thumhumk核的轨迹的数量从每个初始手术侧的中位数从三个减少到两个（P <0.001）。该技术还提供了通过关联两个紧密间隔同时记录的神经元之间的放电来检查种群活动的新机会，并且可以用于监视局部电刺激或微注射药理作用的电生理效应。结论：我们的经验表明，使用两个紧密间隔的微电极可以改善微电极定位在微创功能神经外科手术中的实用性。

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