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首页> 外文期刊>Neurosurgery >Surgical construction of an in vivo carotid siphon model to test neurovascular devices.
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Surgical construction of an in vivo carotid siphon model to test neurovascular devices.

机译：体内颈动脉虹吸模型的手术构建，以测试神经血管装置。

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OBJECTIVE: We developed an animal model to evaluate vascular trauma induced by endovascular devices that are proposed for the treatment of cerebrovascular diseases. METHODS: The model was constructed in six domestic swine by elongating the common carotid artery using interpositional grafts. Balloon catheters (n = 3), stents (n = 2), and a snare were tested 9 to 13 days after surgery. Device performance was evaluated by angiography, macroscopic photography, and histopathological examination. RESULTS: Animals tolerated the surgical procedure well, and artificial siphons were thought to provide realistic conditions for device testing. Balloon catheters induced minimal trauma, whereas coronary stents caused severe spasm or thrombosis and extensive macroscopic changes. CONCLUSION: Construction of an in vivo siphon model is feasible and potentially useful for testing neurovascular devices.
机译：目的：我们开发了一种动物模型来评估由拟议用于治疗脑血管疾病的血管内装置引起的血管损伤。方法：该模型是在六只家猪中通过使用介入移植物拉长颈总动脉而构建的。术后9至13天对球囊导管（n = 3），支架（n = 2）和圈套器进行了测试。通过血管造影，宏观摄影和组织病理学检查评估设备性能。结果：动物对外科手术的耐受性良好，人工虹吸被认为为设备测试提供了现实条件。球囊导管引起的损伤最小，而冠状动脉支架引起严重的痉挛或血栓形成以及广泛的宏观变化。结论：体内虹吸模型的建立是可行的，并且可能对测试神经血管装置有用。

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