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首页> 外文期刊>Biochemistry >The Role of beta 1 Integrin Subfamily in Anchorage-Dependent Apoptosis of Breast Carcinoma Cells Differing in Multidrug Resistance
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The Role of beta 1 Integrin Subfamily in Anchorage-Dependent Apoptosis of Breast Carcinoma Cells Differing in Multidrug Resistance

机译：β1整联蛋白亚家族在不同药物耐药性的乳腺癌细胞的锚固依赖性细胞凋亡中的作用

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摘要

Integrin expression was investigated in MCF-7 human breast adenocarcinoma line and in the MCF-7Dox line,which was selected from MCF-7 by a resistance to multiple antitumor drugs(MDR).We have shown that acquisition of MDR was accompanied by a drastically reduced expression of some integrins of the beta 1-subfamily(alpha 2 beta 1,alpha 3 beta 1,alpha 6 beta 1)and of avp5 intergin in the adenocarcinoma cells.In contrast,expression of alpha 5 beta 1 integrin was markedly increased in the MDR cells.Along with multiple antitumor drug resistance,MCF-7Dox cells demonstrate elevated resistance to anchorage-dependent apoptosis(anoikis)and enhanced in vitro invasive activity.To elucidate the implication of beta 1-integrins in the above phenotypic modifications,the effect of beta 1-integrin signaling was assayed.Stimulation of pi-mediated signaling was accomplished by treating of the cells with antibodies to the beta 1-subunit common for members of the beta 1-subfamily.These data show that activation of pl-integrin signaling markedly upregulated anoikis of the adenocarcinoma cells.
机译：研究了MCF-7人乳腺癌细胞系和MCF-7Dox细胞中的整合素表达，MC​​F-7Dox细胞系通过对多种抗肿瘤药物（MDR）的耐药性从MCF-7中选择而来。减少了腺癌细胞中β1亚家族（α2β1，α3β1，α6β1）和avp5整合素的一些整合素的表达。相比之下，α5β1整合素的表达显着增加。 MCF-7Dox细胞具有多重抗肿瘤耐药性，对锚定依赖性凋亡（anoikis）的抵抗力增强，并具有增强的体外侵袭活性。为阐明β1整合素在上述表型修饰中的作用分析了β1-整合素信号转导的信号，通过用β1-亚家族成员常见的β1-亚基抗体处理细胞来完成pi介导的信号转导。整合素的离子化信号显着上调了腺癌细胞的凋亡。

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