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首页> 外文期刊>Neurosurgery >Stereotactic radiosurgery: adjacent tissue injury and response after high-dose single fraction radiation: Part I--Histology, imaging, and molecular events.
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Stereotactic radiosurgery: adjacent tissue injury and response after high-dose single fraction radiation: Part I--Histology, imaging, and molecular events.

机译：立体定向放射外科：大剂量单次放射后邻近组织的损伤和反应：第一部分-组织学，影像学和分子事件。

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摘要

Radiosurgery is now the preferred treatment modality for many intracranial disease processes. Although almost 50 years have passed since it was introduced as a tool to treat neurological disease, investigations into its effects on normal tissues of the central nervous system are still ongoing. The need for these continuing studies must be underscored. A fundamental understanding of the brain parenchymal response to radiosurgery would permit development of strategies that would enhance and potentiate the radiosurgical treatment effects on diseased tissue while mitigating injury to normal structures. To date, most studies on the response of the central nervous system to radiosurgery have been performed on brain tissue in the absence of pathological lesions, such as benign tumors or metastases. Although instructive, these investigations fail to emulate the majority of clinical scenarios that involve radiosurgical treatment of specific lesions surrounded by normal brain parenchyma. This article is the first in a two-part series that addresses the brain parenchyma's response to radiosurgery. This first article analyzes the histological, radiographic, and molecular data gathered regarding the brain parenchymal response to radiosurgery and aims to suggest future studies that could enhance our understanding of the topic. The second article in the series begins by discussing strategies for radiosurgical therapeutic enhancement. It concludes by focusing on strategies for mitigation and repair of radiation-induced brain injury.
机译：现在，放射外科是许多颅内疾病过程的首选治疗方式。尽管自从将它作为一种治疗神经系统疾病的工具以来已经过去了近50年，但有关它对中枢神经系统正常组织的影响的研究仍在继续。必须强调对这些继续研究的需求。对脑部对放射外科实质反应的基本了解将允许制定策略，以增强和增强对患病组织的放射外科治疗效果，同时减轻对正常结构的伤害。迄今为止，大多数关于中枢神经系统对放射外科手术反应的研究都是在没有病理性病变（例如良性肿瘤或转移灶）的情况下在脑组织上进行的。尽管具有指导意义，但这些研究未能模仿大多数涉及放射外科治疗被正常脑实质包围的特定病变的临床方案。本文是由两部分组成的系列文章的第一篇，该系列文章探讨了脑实质对放射外科手术的反应。这篇第一篇文章分析了收集的有关脑实质对放射外科手术反应的组织学，影像学和分子数据，旨在为将来的研究提出建议，以增强我们对该主题的理解。该系列的第二篇文章首先讨论了放射外科治疗增强的策略。最后，重点介绍了缓解和修复辐射引起的脑损伤的策略。

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