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5-aminolevulinic acid-guided resection of bone-invasive meningiomas

机译:5-氨基乙酰丙酸导向的骨浸润性脑膜瘤切除术

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摘要

Hyperostosis associated with intracranial meningiomas is a well-described entity. Al Mefty and his colleagues reported in a large series that hyperostosis associated with meningiomas is caused in up to 96% of cases by tumor invasion of the bone.7 Radical resection of these meningiomas can be difficult to achieve because bone infiltration can be hard to recognize.2 For this reason, new techniques that make it possible to intraoperatively identify cranial involvement of tumor are welcome. 5-aminolevulinic acid (5-ALA)–guided resection is an emerging technique in neurooncological surgery that has been largely reported to improve the extent of resection and to influence overall survival of patients affected by malignant gliomas. Conversely, the role of fluorescence-guided surgery on meningiomas remains unclear.
机译:与颅内脑膜瘤相关的骨肥厚是一个很好描述的实体。 Al Mefty和他的同事大量报道,在高达96%的病例中,由于骨肿瘤浸润引起与脑膜瘤相关的骨肥大7。由于难以发现骨浸润,很难实现对这些脑膜瘤的根治性切除。 .2由于这个原因,欢迎有可能在术中识别出颅骨受累的新技术。 5-氨基乙酰丙酸(5-ALA)引导的切除术是神经肿瘤外科手术中的一种新兴技术,据报道,该技术可改善切除范围并影响受恶性神经胶质瘤影响的患者的整体生存。相反,荧光引导手术对脑膜瘤的作用尚不清楚。

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