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首页> 外文期刊>Neurosurgical focus >Therapeutic strategies to improve drug delivery across the blood-brain barrier
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Therapeutic strategies to improve drug delivery across the blood-brain barrier

机译：改善跨血脑屏障药物输送的治疗策略

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Resection of brain tumors is followed by chemotherapy and radiation to ablate remaining malignant cell populations. Targeting these populations stands to reduce tumor recurrence and offer the promise of more complete therapy. Thus, improving access to the tumor, while leaving normal brain tissue unscathed, is a critical pursuit. A central challenge in this endeavor lies in the limited delivery of therapeutics to the tumor itself. The blood-brain barrier (BBB) is responsible for much of this difficulty but also provides an essential separation from systemic circulation. Due to the BBB's physical and chemical constraints, many current therapies, from cytotoxic drugs to antibody-based proteins, cannot gain access to the tumor. This review describes the characteristics of the BBB and associated changes wrought by the presence of a tumor. Current strategies for enhancing the delivery of therapies across the BBB to the tumor will be discussed, with a distinction made between strategies that seek to disrupt the BBB and those that aim to circumvent it.
机译：切除脑肿瘤后，进行化学疗法和放射治疗，以消融剩余的恶性细胞群。针对这些人群将减少肿瘤复发，并有望提供更完整的治疗方法。因此，在不损害正常脑组织的情况下，改善进入肿瘤的途径是一项至关重要的追求。在这一努力中的主要挑战在于治疗剂向肿瘤本身的有限递送。血脑屏障（BBB）是造成这种困难的主要原因，但也提供了与全身循环的本质隔离。由于BBB的物理和化学限制，从细胞毒性药物到基于抗体的蛋白质的许多当前疗法无法进入肿瘤。这篇综述描述了血脑屏障的特征以及由于肿瘤的存在而引起的相关变化。将讨论目前用于增强跨血脑屏障对肿瘤的治疗递送的策略，并在试图破坏血脑屏障的策略和旨在绕过血脑屏障的策略之间进行区分。

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