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Optogenetic modulation in stroke recovery

机译:脑卒中恢复中的光遗传调制

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摘要

Stroke is one of the leading contributors to morbidity, mortality, and health care costs in the United States. Although several preclinical strategies have shown promise in the laboratory, few have succeeded in the clinical setting. Optogenetics represents a promising molecular tool, which enables highly specific circuit-level neuromodulation. Here, the conceptual background and preclinical body of evidence for optogenetics are reviewed, and translational considerations in stroke recovery are discussed.
机译:中风是美国发病率,死亡率和医疗保健成本的主要贡献者之一。尽管一些临床前策略已在实验室中显示出希望,但在临床环境中却很少成功。光遗传学是一种有前途的分子工具,可以实现高度特异性的电路级神经调节。在这里,回顾了光遗传学的概念背景和临床前证据,并讨论了卒中恢复中的翻译注意事项。

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