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Moyamoya disease: Functional and neurocognitive outcomes in the pediatric and adult populations

机译：Moyamoya疾病：儿童和成人人群的功能和神经认知结果

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摘要

Object: Moyamoya disease is an occlusive cerebrovascular disorder commonly resulting in neurocognitive impairment. The cognitive outcome parameters commonly affected are intelligence, memory, executive function, and quality of life. In this paper, the authors review the existing literature on cognitive and clinical outcomes in adult and pediatric moyamoya populations separately. Methods: A systematic review of the cognitive and clinical outcome literature was performed using the PubMed/MEDLINE database. Outcomes data were contrasted between adult and pediatric populations. Results: Intelligence is the main cognitive outcome parameter affected in pediatric patients with moyamoya disease, whereas adults most commonly suffer from executive function impairment. Memory has not been studied sufficiently in pediatric patients, and its dysfunction in the adult population remains controversial. Quality of life has not been studied appropriately in either population. Surgical revascularization is the only beneficial treatment option, and a combination of direct and indirect bypass techniques has shown benefit, but the impact on the above-mentioned parameters has not been sufficiently elucidated. Conclusions: Moyamoya disease affects the cognition and daily function in pediatric patients to a greater extent than in adult patients. Due to the rarity of the disease, there is a distinct lack of high-level evidence regarding cognitive and clinical outcomes.
机译：目的：烟雾病是一种闭塞性脑血管疾病，通常会导致神经认知障碍。通常受影响的认知结果参数是智力，记忆力，执行功能和生活质量。在本文中，作者分别回顾了有关成人和儿童烟雾病人群的认知和临床结果的现有文献。方法：使用PubMed / MEDLINE数据库对认知和临床结果文献进行系统评价。结果数据在成人和儿童人群之间进行了对比。结果：智力是受烟雾病患儿影响的主要认知结局参数，而成年人最常遭受执行功能障碍。在小儿患者中尚未对记忆进行足够的研究，并且其在成人人群中的功能障碍仍存在争议。两种人群的生活质量都没有得到适当的研究。手术血运重建是唯一有益的治疗选择，并且直接和间接旁路技术的结合已显示出益处，但尚未充分阐明对上述参数的影响。结论：Moyamoya疾病对儿童患者的认知和日常功能的影响比对成人患者的影响更大。由于该疾病的稀有性，显然缺乏有关认知和临床结果的高级证据。

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