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首页> 外文期刊>Neurosurgical focus >Using ex vivo proton magnetic resonance spectroscopy to reveal associations between biochemical and biological features of meningiomas
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Using ex vivo proton magnetic resonance spectroscopy to reveal associations between biochemical and biological features of meningiomas

机译：使用离体质子磁共振波谱揭示脑膜瘤的生化和生物学特征之间的关联

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Object: The goal in this study was to determine if proton ( 1H) MR spectroscopy can differentiate meningioma grade and is associated with interpretations of biological behavior; the study was performed using ex vivo highresolution spectra indicating metabolic characteristics. Methods: Sixty-eight resected tissue samples of meningiomas were examined using ex vivo 1H MR spectroscopy. Of these meningiomas, 46 were WHO Grade I, 14 were WHO Grade II, and 8 were WHO Grade III. Fifty-nine were primary meningiomas and 9 were recurrences. Invasion of adjacent tissue (dura mater, bone, venous sinus, brain) was found in 32 cases. Thirty-nine meningiomas did not rapidly recur (as defined by expansion on MR imaging within a 5-year follow-up period), whereas rapid recurrence was confirmed in 24 meningiomas, and follow-up status was unknown in 5 cases. Results: The absolute concentrations of total alanine and creatine were decreased in high-grade compared with low-grade meningiomas, as was the ratio of glycine to alanine (all p 0.05). Additionally, alanine and the glycine/alanine ratio distinguished between primary and recurrent meningiomas (all p 0.05). Finally, the absolute concentrations of alanine and creatine, and the glycine/alanine and choline/glutamate ratios were associated with rapid recurrence (p 0.05). Conclusions: These data indicate that meningioma tissue can be characterized by metabolic parameters that are not typically identified by histopathological analysis alone. Creatine, glycine, and alanine may be used as markers of meningioma grade, recurrence, and the likelihood of rapid recurrence. These data validate a previous study of a separate group of Grade I meningiomas.
机译：目的：本研究的目的是确定质子（1H）MR光谱学是否可以区分脑膜瘤等级，并与生物学行为的解释有关;该研究使用指示代谢特征的离体高分辨率光谱进行。方法：使用离体1H MR光谱检查了68个切除的脑膜瘤组织样本。在这些脑膜瘤中，46例为WHO I级，14例为WHO II级，8例为WHO III级。 59例为原发性脑膜瘤，9例为复发。发现32例侵犯邻近组织（硬脑膜，骨骼，静脉窦，脑）。 39例脑膜瘤并未迅速复发（定义为5年随访期内MR成像扩大），而24例脑膜瘤确诊为快速复发，其中5例的随访状态未知。结果：与低度脑膜瘤相比，高度脑膜瘤中总丙氨酸和肌酸的绝对浓度降低，甘氨酸与丙氨酸之比也降低（所有p <0.05）。此外，丙氨酸和甘氨酸/丙氨酸比值在原发性脑膜瘤和复发性脑膜瘤之间有所区别（所有p <0.05）。最后，丙氨酸和肌酸的绝对浓度以及甘氨酸/丙氨酸和胆碱/谷氨酸的比率与复发率高有关（p <0.05）。结论：这些数据表明脑膜瘤组织可以通过代谢参数来表征，而这些代谢参数通常不能单独通过组织病理学分析来识别。肌酸，甘氨酸和丙氨酸可用作脑膜瘤分级，复发和快速复发可能性的标志物。这些数据验证了先前对另一组I级脑膜瘤的研究。

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