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Deep brain stimulation between 1947 and 1987: the untold story

机译:1947年至1987年间的深层大脑刺激:不为人知的故事

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Deep brain stimulation (DBS) is the most rapidly expanding field in neurosurgery. Movement disorders are well-established indications for DBS, and a number of other neurological and psychiatric indications are currently being investigated.Numerous contemporary opinions, reviews, and viewpoints on DBS fail to provide a comprehensive account of how this method came into being. Misconceptions in the narrative history of DBS conveyed by the wealth of literature published over the last 2 decades can be summarized as follows: Deep brain stimulation was invented in 1987. The utility of high-frequency stimulation was also discovered in 1987. Lesional surgery preceded DBS. Deep brain stimulation was first used in the treatment of movement disorders and was subsequently used in the treatment of psychiatric and behavioral disorders. Reports of nonmotor effects of subthalamic nucleus DBS prompted its use in psychiatric illness. Early surgical interventions for psychiatric illness failed to adopt a multidisciplinary approach; neurosurgeons often worked "in isolation" from other medical specialists. The involvement of neuro-ethicists and multidisciplinary teams are novel standards introduced in the modern practice of DBS for mental illness that are essential in avoiding the unethical behavior of bygone eras.In this paper, the authors examined each of these messages in the light of literature published since 1947 and formed the following conclusions. Chronic stimulation of subcortical structures was first used in the early 1950s, very soon after the introduction of human stereotaxy. Studies and debate on the stimulation frequency most likely to achieve desirable results and avoid side effects date back to the early days of DBS; several authors advocated the use of "high" frequency, although the exact frequency was not always specified. Ablative surgery and electrical stimulation developed in parallel, practically since the introduction of human stereotactic surgery. The first appl
机译:深度脑刺激(DBS)是神经外科领域中发展最快的领域。运动障碍是公认的DBS适应症,目前正在研究其他许多神经和精神病适应症。有关DBS的许多现代观点,评论和观点未能全面介绍这种方法的产生方式。在过去的20年中,大量文献所传达的对DBS叙事历史的误解可归纳如下:1987年发明了深部脑刺激法。1987年也发现了高频刺激的效用。 。深度脑刺激首先用于运动障碍的治疗,随后被用于精神病和行为障碍的治疗。关于丘脑下核DBS的非运动性影响的报道促使其在精神疾病中使用。精神疾病的早期外科手术未能采用多学科方法。神经外科医师通常是与其他医学专家“隔离”地工作的。神经伦理学家和多学科团队的参与是现代DBS精神疾病实践中引入的新标准,对于避免过去时代的不道德行为至关重要。在本文中,作者根据文献研究了每种信息自1947年以来发表的论文并得出以下结论。皮层下结构的慢性刺激最早是在1950年代初使用的,这是在引入人体立体定向后不久。关于最有可能取得理想结果并避免副作用的刺激频率的研究和辩论可以追溯到DBS的早期。一些作者主张使用“高”频率,尽管并不总是指定确切的频率。消融手术和电刺激并行发展,实际上是自引入人类立体定向手术以来。第一次申请

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