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Efficacy, Safety, and Potential Clinical Utility of CETP Inhibition

机译:CETP抑制的功效,安全性和潜在临床用途

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摘要

High-density lipoprotein (HDL) has proved to be a more complicated lipoprotein than was once believed. However, it is still clear that lower high-density-lipoprotein cholesterol (HDL-C) values are linked with increased cardiovascular (CV) risks, while higher HDL-C values in a population are associated with lower CV risks. There are data that indicate that raising HDL-C reduces future CV risk.1 The Coronary Drug Project showed that niacin-based therapy reduces mortality, while the Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT) and the Helsinki Heart Study demonstrated that use of fibrates reduces composite endpoints.
机译:高密度脂蛋白(HDL)已被证明是比以前认为更复杂的脂蛋白。但是,仍然很清楚,高密度脂蛋白胆固醇(HDL-C)值较低与心血管(CV)风险增加有关,而人群中HDL-C值较高与CV风险较低有关。有数据表明提高HDL-C可以降低未来的CV风险。1冠心病药物项目显示,以烟酸为基础的治疗可降低死亡率,而退伍军人事务高密度脂蛋白干预试验(VA-HIT)和赫尔辛基心脏研究证明使用贝特类药物减少了复合终点。

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