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The HDL Component of Residual Risk: Where Are We Now?

机译:HDL残余风险的组成部分:我们现在在哪里?

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Many statin trials that have shown a fairly linear relationship between low-density-lipopro-tein cholesterol (LDL-C) and cardiovascular events. This has given rise to the belief that if LDL-C levels are reduced to a very low level, the risk associated with a low level of high-density-lipoprotein cholesterol (HDL-C) disappears. However, the Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial cast doubt on this assumption, as it did not show the same relationship that has been seen in other studies of primary and secondary prevention. The JUPITER trial population consisted of patients with elevated C-reactive protein (CRP)
机译:许多他汀类药物试验表明,低密度脂蛋白胆固醇(LDL-C)与心血管事件之间存在线性关系。这导致人们相信,如果将LDL-C水平降低到非常低的水平,则与低水平的高密度脂蛋白胆固醇(HDL-C)相关的风险就会消失。但是,在一级预防中使用他汀类药物的理由:瑞舒伐他汀的干预试验(JUPITER)试验对该假设表示怀疑,因为它没有显示出与其他一级和二级预防研究相同的关系。 JUPITER试验人群由C反应蛋白(CRP)升高的患者组成

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