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首页> 外文期刊>Biochemistry >Pentaspan Membrane Glycoprotein,Prominin-1,Is Involved in Glucose Metabolism and Cytoskeleton Alteration
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Pentaspan Membrane Glycoprotein,Prominin-1,Is Involved in Glucose Metabolism and Cytoskeleton Alteration

机译：五角跨膜糖蛋白Prominin-1，参与葡萄糖代谢和细胞骨架的改变。

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This study constitutes the first report revealing the participation of prominin-1 in glucose metabolism and cytoskeleton alteration.Upon stimulation with high glucose,the expression of prominin-1 was up-regulated with concomitant down-regulation of its phosphorylation.Prominin-1 mutated at its phosphorylation site inflicted a global change in the expression of several genes associated with glucose metabolism in L6 myotube cells.Further,the over-expression of pro-minin-1 promoted glucose uptake in these cells.Prominin-1 undergoes sustained repression of its expression during confluence and differentiation of L6 myotube cells.The expression of prominin-1 in the MDCK cell modulated cell morphology and promoted cellular migration.These data imply that prominin-1 is involved in glucose metabolism and may regulate cellular glucose through its effect on cytoskeleton.
机译：这项研究是第一个揭示prominin-1参与葡萄糖代谢和细胞骨架改变的报告。在高葡萄糖刺激下，prominin-1的表达上调而其磷酸化随之下调。prominin-1在它的磷酸化位点导致L6肌管细胞中与葡萄糖代谢有关的几个基因的表达发生全局变化。此外，过表达prominin-1促进了这些细胞中葡萄糖的摄取。Prominin-1受到其表达的持续抑制。 MDK细胞中prominin-1的表达调节细胞形态并促进细胞迁移，这些数据表明prominin-1参与葡萄糖代谢，并可能通过其对细胞骨架的作用来调节细胞葡萄糖。

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