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首页> 外文期刊>Nordic journal of psychiatry. >Psychomotor and cognitive deficits as predictors of 5-year outcome in first-episode schizophrenia
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Psychomotor and cognitive deficits as predictors of 5-year outcome in first-episode schizophrenia

机译：心理运动和认知功能障碍可预测首发精神分裂症患者5年预后

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Background: Cognitive deficits are common in schizophrenia but the predictive value of these deficits for long-term outcome in first-episode patients is unclear. Aims: We aimed to investigate associations of performance in psychomotor and cognitive tests with a 5-year functional and symptomatic outcome. Methods: After clinical stabilization, patients with a first schizophrenia spectrum diagnosis (n = 46) were assessed for global cognitive function [Synonyms, Reasoning, and Block Design (SRB)], psychomotor speed [Trail Making Test (TMT) and finger tapping] and verbal learning (Claeson-Dahl Verbal Learning Test). The subsequent 5-year outcome regarding independent living, occupational and social function, and symptomatic remission status was assessed. Results: Low psychomotor speed was associated with poor social function 5 years later, with an odds ratio (OR) of 3.37 and a 95% confidence interval (CI) of 1.08-10.51, adjusted for antipsychotic drug use. Better performance on finger tapping with the non-dominant hand was associated with an increased risk of a 5-year symptomatic non-remission (adjusted OR = 0.42, CI 0.19-0.96). Occupational function and independent living were not significantly associated with any of the investigated tests. Conclusions: Psychomotor speed is associated with a long-term outcome regarding social function and symptom remission in patients with first-episode schizophrenia.
机译：背景：认知缺陷在精神分裂症中很常见，但是这些缺陷对于首发患者长期预后的预测价值尚不清楚。目的：我们旨在研究心理运动和认知测试中的表现与5年功能和症状结果的相关性。方法：在临床稳定后，对首次精神分裂症频谱诊断（n = 46）的患者进行整体认知功能[同义词，推理和模块设计（SRB）]，心理运动速度[足迹制作测试（TMT）和手指敲击]的评估和言语学习（Claeson-Dahl言语学习测试）。随后评估了有关独立生活，职业和社会功能以及症状缓解状态的5年结局。结果：低精神运动速度与5年后的社交功能差有关，比值比（OR）为3.37，95％置信区间（CI）为1.08-10.51（针对抗精神病药物使用进行了调整）。用非优势手敲击手指的更好性能与5年症状不缓解的风险增加相关（校正OR = 0.42，CI 0.19-0.96）。职业功能和独立生活与任何调查的测试均无显着相关。结论：首发精神分裂症患者的精神运动速度与社会功能和症状缓解的长期结果相关。

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