...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nordic journal of psychiatry. >Cerebrospinal fluid monoamine metabolites and suicide.
【24h】

Cerebrospinal fluid monoamine metabolites and suicide.

机译：脑脊液单胺代谢产物和自杀。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Prospective studies of the serotonergic system and suicide report that low 5-hydroxyindolacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) and a history of attempted suicide predict suicide risk. Low CSF homovanillic acid (HVA) is reported to be associated with past and future lethality of suicide attempts but not with suicide. The interrelationships between monoamine metabolites, violent method, suicide intent and lethality of suicidal behaviour are complex. We hypothesized that CSF 5-HIAA and HVA levels are related to suicide intent, violence and lethality of suicidal behaviour. Fifteen male suicide attempters admitted to a psychiatric ward at the Karolinska University Hospital and eight healthy male volunteers were submitted to lumbar puncture and CSF 5-HIAA and HVA were assayed. Suicide intent with the Beck Suicide Intent Scale (SIS), lethality and violence of suicidal behaviour were assessed. All patients were followed up for causes of death. Six suicides and one fatal accident were identified with death certificates. Mean CSF 5-HIAA but not CSF HVA differed between suicides and survivors. Violent suicides had higher suicide intent and CSF 5-HIAA than non-violent suicides. In violent suicides, CSF 5-HIAA levels were negatively correlated with SIS. Greater suicide intent may be associated with greater aggressive intent and predicts a violent suicide method.
机译：血清素能系统和自杀的前瞻性研究报道，脑脊液（CSF）中的低5-羟吲哚乙酸（5-HIAA）和自杀未遂的历史可预测自杀风险。据报道，低脑脊液高香草酸（HVA）与过去和将来自杀未遂的致死率有关，但与自杀无关。单胺代谢物，暴力方法，自杀意图和自杀行为的致死性之间的相互关系是复杂的。我们假设CSF 5-HIAA和HVA水平与自杀意图，暴力行为和自杀行为的致死率有关。卡罗林斯卡大学医院的精神病房收治了15名男性自杀未遂者，并对8名健康男性志愿者进行了腰椎穿刺，并对CSF 5-HIAA和HVA进行了检测。用贝克自杀意向量表（SIS），自杀行为的杀伤力和暴力评估自杀意图。所有患者均接受了死亡原因的随访。死亡证明有6例自杀和1例致命事故。自杀者和幸存者之间的平均CSF 5-HIAA不同，但CSF HVA没有差异。暴力自杀者的自杀意图和CSF 5-HIAA高于非暴力自杀者。在暴力自杀中，CSF 5-HIAA水平与SIS呈负相关。更大的自杀意图可能与更大的攻击意图有关，并预示着暴力自杀方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号