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Immune Proteasomes in the Developing Rat Thymus

机译：发育中的大鼠胸腺中的免疫蛋白酶体

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摘要

The age dynamics of the content of the immune proteasome subunits LMP2 and LMP7 in rat thymus during prenatal and early postnatal ontogeny was studied. The LMP2 and LMP7 immune subunits were detected by Western blotting already by the 18th day of embryonic development, their amount increased to the 21st day to the level characteristic of the postnatal state. Double immunofluorescent labeling showed that in the thymus tissue the largest amount of LMP2 and LMP7 is localized in epithelial cells, whereas the level of their expression in thymocytes is lower. The results suggest that the establishment in thymus of selection processes, which depend on activity of immune proteasomes, can take place already in prenatal ontogeny. Analysis of age dynamics of the natural apoptosis level in thymocytes also favors this supposition. The presence of immune proteasomes in thymocytes during perinatal ontogeny suggests that, besides the antigen presentation, immunoproteasomes may possess other important functions.
机译：研究了大鼠胸腺在产前和产后早期个体发育过程中免疫蛋白酶体亚基LMP2和LMP7含量的年龄动态。 LMP2和LMP7免疫亚基已经在胚胎发育的第18天通过蛋白质印迹法检测到，它们的数量增加到21天达到了产后状态的水平。双重免疫荧光标记显示，在胸腺组织中，最大量的LMP2和LMP7定位在上皮细胞中，而它们在胸腺细胞中的表达水平较低。结果表明，取决于免疫蛋白酶体活性的选择过程在胸腺中的建立已经可以在产前个体发育中进行。胸腺细胞中自然凋亡水平的年龄动态分析也支持这种假设。围产期个体发育过程中胸腺细胞中存在免疫蛋白酶体，这表明，除了抗原呈递外，免疫蛋白酶体可能还具有其他重要功能。

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