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首页> 外文期刊>Nordic journal of psychiatry. >Common laboratory measures of global health may not be suited to assess, discriminate or predict chronic stress effects on biological systems.
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Common laboratory measures of global health may not be suited to assess, discriminate or predict chronic stress effects on biological systems.

机译：通用的全球健康实验室措施可能不适合评估，区分或预测对生物系统的慢性压力影响。

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BACKGROUND: There is a longstanding discussion that prolonged psychological stress can have negative somatic effects, especially in respect to endocrinological and immunological changes. Yet, the clinical significance of these findings is still unclear. Patients with prolonged stress should show more signs and symptoms of related illnesses. AIM: The question we like to answer in this study is: are laboratory measures of global health suited to assess, discriminate or predict chronic psychological stress effects on biological systems? METHODS: Included were 50 inpatients who were suffering from post-traumatic embitterment disorder (PTED), a condition that causes persistent and intense psychological distress. They were compared with a group of 50 matched control patients with unselected psychosomatic disorders but no immediate stress and strain. Gender distribution and age were the same in both samples because of the matching (60% women; mean age: 49 years). PTED patients had an average duration of illness of 31.7 (+/-35.5) months. In the SCL-90 they showed an average GSI score of 1.13 (+/-0.55) compared with 0.74 (+/-0.50) in the controls, as indicator of their increased psychological strain. Between groups, we compared the results of 24 laboratory tests, which can be seen as indicators of functioning of all important body systems. Results: There was no significant difference in the results of laboratory tests between groups and especially no indicators for different rates of immunological or inflammatory illnesses. CONCLUSION: Laboratory measures of global health may not be suited to assess, discriminate or predict psychological chronic stress effects on important biological systems.
机译：背景：长期以来的讨论认为，长期的心理压力可能会对身体产生负面影响，尤其是在内分泌和免疫学方面。然而，这些发现的临床意义仍不清楚。长期紧张的患者应显示更多相关疾病的体征和症状。目的：我们在这项研究中想要回答的问题是：全球健康的实验室指标是否适合评估，区分或预测对生物系统的慢性心理压力影响？方法：包括50名患有创伤后情绪低落症（PTED）的住院患者，这种疾病会引起持续而强烈的心理困扰。将他们与一组50名匹配的对照患者进行比较，这些患者患有未选择的心身疾病，但没有立即的压力和劳累。由于匹配，两个样本的性别分布和年龄均相同（60％为女性;平均年龄为49岁）。 PTED患者的平均病程为31.7（+/- 35.5）个月。在SCL-90中，他们的平均GSI得分为1.13（+/- 0.55），而对照组的平均GSI得分为0.74（+/- 0.50），这表明他们的心理压力增加了。在两组之间，我们比较了24个实验室测试的结果，这些结果可以看作是所有重要人体系统功能的指标。结果：两组之间的实验室测试结果无显着差异，尤其是没有针对不同免疫或炎性疾病发生率的指标。结论：全球健康的实验室指标可能不适合评估，区分或预测心理慢性应激对重要生物系统的影响。

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