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首页> 外文期刊>Nordic journal of psychiatry. >Comparison of the antidepressant effects of venlafaxine and dosulepin in a naturalistic setting.
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Comparison of the antidepressant effects of venlafaxine and dosulepin in a naturalistic setting.

机译：文拉法辛和多苏平在自然环境中的抗抑郁作用比较。

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The relative efficacy of the various classes of antidepressants has not been established. Observational studies in naturalistic settings are important in evaluating treatment outcomes with antidepressants, since controlled clinical trials include only a minority of patients present in clinical practice. This study sought to evaluate in a naturalistic setting the treatment outcomes of dosulepin and venlafaxine for patients with depressive episodes. At the university hospital in Copenhagen, Denmark, between 1998 and early 2001, the first-line treatment for psychiatric inpatients with depression was dosulepin; after that time, venlafaxine was the first-line medication. We compared the treatment outcomes among inpatients during the respective periods. There was no significant difference in the primary outcome parameters between the two groups. A tendency in favour of dosulepin confirmed by a post-hoc analysis suggested that the failure to achieve significant difference was related to a type 2 error. However, missing data and possible confounders related to the different treatment periods weaken the results. This naturalistic study showed a non-significant trend for poorer treatment outcomes (probably because of an underpowered design) after replacing dosulepin with venlafaxine as first-line drug for depression in a naturalistic inpatient setting.
机译：尚未确定各种抗抑郁药的相对功效。在自然环境中的观察性研究对于评估抗抑郁药的治疗效果非常重要，因为受控临床试验仅包括临床实践中的少数患者。这项研究试图在自然环境中评估dosulepin和venlafaxine对抑郁症患者的治疗效果。 1998年至2001年初之间，在丹麦哥本哈根的大学医院中，治疗抑郁症的精神病患者的一线治疗方法是dosulepin。在那之后，文拉法辛是一线药物。我们比较了各个时期住院患者的治疗结果。两组之间的主要结局参数没有显着差异。事后分析证实了倾向于使用dosulepin的趋势表明，未能实现显着差异与2型错误有关。但是，缺少数据以及与不同治疗时期相关的可能混杂因素会削弱结果。这项自然主义的研究表明，用文拉法辛代替多塞平作为抑郁症的一线药物后，治疗效果较差的趋势不明显（可能是由于设计能力不足）。

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