• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nordic journal of psychiatry. >Role of T helper lymphokines in the immune-inflammatory pathophysiology of schizophrenia: Systematic review and meta-analysis
【24h】

Role of T helper lymphokines in the immune-inflammatory pathophysiology of schizophrenia: Systematic review and meta-analysis

机译：T辅助淋巴因子在精神分裂症免疫炎症病理生理中的作用：系统评价和荟萃分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Schizophrenia is highly complex multifactorial psychiatric disorder with poorly defined etiopathophysiology, which also has manifestations in the immune system. Aims: The aim of this review is to meta-analyze the available evidence regarding the role of immune activation indicated by the T helper cells in order to evaluate etiopathophysiological links between the immune system and schizophrenia. Methods: A literature search was performed in multiple electronic databases for relevant research papers published between 1990 and May 2014. Meta-analyses were conducted under both random- (REM) and -fixed-effect models (PIN) by calculating weighted mean differences with 95% confidence intervals. Heterogeneity was assessed with the I-2 index. Results: Twenty-one studies were selected after observing inclusion and exclusion criteria. In vitro interferon-gamma (INF-gamma) and interieukin (IL)-2 production was significantly lower in the schizophrenic patients compared with non-schizophrenic control individuals under both FEM and REM. Serum levels of IL-2 and serum/in vitro IL-4 were not significantly different in both groups under both IFEM and REM. Overall Th1:Th2 ratio (INF-gamma:IL-4 and IL-2:IL-4) in the serum samples was significantly deflected towards Th2 under both models in the serum samples (-0.33 [-0.59 to -0.061; P<0.03, FEM and -2.44 [- 4.27 to -0.601; P< 0.009, REM) but in vitro production Thl:Th2 ratio (INF-gamma:IL-4 and IL-2:IL-4) was deflected towards Thi under both the models (1.11 [0.45-1.781; P< 0.002, FL and 6.68 [0.72 12.64]; P< 0.03, REM). Conclusions: Whereas theltil:Th2 ratio in the serum samples deflected towards T2, in vitro Thl:Th2 ratio favored Thi when the individual study data were meta-analyzed.
机译：背景：精神分裂症是高度复杂的多因素精神病，病因生理学定义不清，在免疫系统中也有表现。目的：本综述的目的是对有关T辅助细胞指示的免疫激活作用的现有证据进行荟萃分析，以评估免疫系统与精神分裂症之间的病因生理联系。方法：在多个电子数据库中对1990年至2014年5月之间发表的相关研究论文进行文献检索。通过随机加权（REM）和固定效应模型（PIN）进行荟萃分析，计算加权均数差异为95 ％ 置信区间。异质性用I-2指数评估。结果：在观察纳入和排除标准后选择了二十一项研究。在FEM和REM下，精神分裂症患者的体外干扰素-γ（INF-γ）和白细胞介素（IL）-2的产生显着低于非精神分裂症对照个体。在IFEM和REM下，两组的血清IL-2水平和血清/体外IL-4均无显着差异。在两种模型中，血清样品中的总Th1：Th2比率（INF-γ：IL-4和IL-2：IL-4）均显着偏向Th2（-0.33 [-0.59至-0.061; P < 0.03，FEM和-2.44 [-4.27至-0.601; P <0.009，REM），但在两种情况下，体外产生的Thl：Th2比值（INF-γ：IL-4和IL-2：IL-4）向Thi方向偏移。模型（1.11 [0.45-1.781; P <0.002，FL和6.68 [0.72 12.64]; P <0.03，REM）。结论：尽管血清样本中的泰尔：Th2比值偏向T2，但对个体研究数据进行荟萃分析时，体外Thl：Th2比值偏向Thi。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号