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A systematic review of reboxetine for treating patients with attention deficit hyperactivity disorder

机译：瑞波西汀治疗注意缺陷多动障碍患者的系统评价

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摘要

Background: No published systematic review has ever assessed the efficacy and safety of reboxetine for treating of patients with attention deficit hyperactivity disorder (ADHD). Aim: This systematic review aimed to review the available evidence regarding the efficacy of reboxetine for treating ADHD. Method: The databases of Pubmed/Medline, Google scholar, SCOPUS and Web of Science were searched using the Keywords: "reboxetine", "ADHD" and "attention deficit hyperactivity disorder". The reference lists of the included studies were screened to find any possible other relevant articles. All the non-controlled and controlled clinical trials were included. Results: The current evidence mainly consists of un-controlled studies, such as case series. Only three of 33 studies were controlled clinical trials. They are from single sites and included a sub-sample of patients with ADHD. Conclusion: Non-controlled studies and controlled trials support the promising effect of reboxetine for treating ADHD in a sub-sample of patients that are without co-morbid psychiatric disorder and mental retardation. Reboxetine is tolerated well. However, more controlled trials are needed to reach any firm conclusion.
机译：背景：没有发表的系统评价曾经评估过瑞波西汀治疗注意力缺陷多动障碍（ADHD）患者的疗效和安全性。目的：本系统综述旨在回顾有关瑞波西汀治疗ADHD疗效的现有证据。方法：使用关键词“ reboxetine”，“ ADHD”和“注意缺陷多动障碍”搜索Pubmed / Medline，Google Scholar，SCOPUS和Web of Science的数据库。筛选纳入研究的参考文献列表，以找到其他可能的相关文章。包括所有非对照和对照临床试验。结果：目前的证据主要包括非对照研究，例如病例系列。 33项研究中只有3项是对照临床试验。他们来自单个地点，并包括了多动症患者的子样本。结论：非对照研究和对照试验支持瑞波西汀在无合并症的精神病和智力障碍的患者子样本中治疗多动症的有希望的作用。瑞波西汀耐受性良好。但是，需要更多的对照试验才能得出确切的结论。

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