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Genetic Polymorphism and Variability of Chemical Carcinogenesis

机译：化学致癌基因的遗传多态性和变异性

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摘要

Risk assessment in chemical carcinogenesis involves ratios of several factors. Individual responses of an organism to carcinogenic agents depend on polymorphism of enzymes responsible for metabolic activation/detoxification of carcinogens, DNA repair, and apoptosis, as well as promotion and progression in malignantly transformed cells. The effects of a particular polymorphic variant are manifested only in the case of its high penetrance. An integral effect is formed by the ratio of procarcinogenic and anticarcinogenic effects. The complexity of risk assessment depends on the gene polymorphism mosaic involved, directly or indirectly, in tumorigenesis and upstream/downstream interactions of gene products.
机译：化学致癌的风险评估涉及多个因素的比率。生物体对致癌剂的个体反应取决于致癌物代谢活化/解毒，DNA修复和细胞凋亡以及恶性转化细胞中的促进和进展的酶的多态性。特定多态性变体的效果仅在其高渗透性的情况下才表现出来。致癌作用和抗癌作用之比形成整体作用。风险评估的复杂性取决于直接或间接涉及肿瘤发生和基因产物上游/下游相互作用的基因多态性镶嵌。

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