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首页> 外文期刊>Nordic journal of psychiatry. >Decreased dehydroepiandrosterone sulphate levels in adolescents with post-traumatic stress disorder after single sexual trauma
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Decreased dehydroepiandrosterone sulphate levels in adolescents with post-traumatic stress disorder after single sexual trauma

机译：单一性创伤后创伤后应激障碍青少年的硫酸脱氢表雄酮硫酸盐水平降低

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Background: Recent evidence shows that the hypothalamic-pituitary-adrenal (HPA) axis can be dysregulated in chronic sexual abuse victims with post-traumatic stress disorder (PTSD). We hypothesized that PTSD in adolescents exposed to a single sexual trauma may function as a chronic stressor leading to HPA-axis dysregulation. Aims: The objective of this study was to assess dehydroepiandrosterone sulphate (DHEA-S) and cortisol levels in female adolescents |with single sexual trauma-related PTSD compared to healthy controls. Method: We assessed 20 female adolescent (age 12-18) single sexual trauma victims with PTSD from the Ondokuz Mayis University Department of Child and Adolescent Psychiatry between December 2013 and December 2014. PTSD symptoms were assessed using the Child Depression Inventory (CDI) and Child Posttraumatic Stress Reaction Index (CPSRI). Blood cortisol and DHEA-S were measured in 20 female adolescent sexual abuse victims with PTSD and 20 healthy adolescents after 12-h fasting using the chemiluminescence method. Results: Compared to age-matched controls, female adolescent sexual abuse victims with PTSD had significantly lower DHEA-S levels (U = 70.00, Z = - 3.517, p = 0.01, r = 0.55). There was also a significant negative correlation between DHEA-S and CDI scores (Spearman r = - 0.522, p < 0.01). Conclusions: Decreased DHEA-S levels and correlation with depressive symptoms are evidence for a dysregulated HPA-axis in female adolescent single sexual trauma victims with PTSD. Further research is now recommended with large patient groups in order to maximize generalizations.
机译：背景：最近的证据表明，患有创伤后应激障碍（PTSD）的慢性性虐待受害者的下丘脑-垂体-肾上腺（HPA）轴可能失调。我们假设暴露于单一性创伤的青少年中的PTSD可能充当导致HPA轴失调的慢性应激源。目的：这项研究的目的是评估与健康对照相比，患有单一性创伤相关PTSD的女性青少年的脱氢表雄酮硫酸盐（DHEA-S）和皮质醇水平。方法：我们评估了2013年12月至2014年12月间Ondokuz Mayis大学儿童与青少年精神病学系的20名女性青少年（12-18岁）患有PTSD的单性创伤受害者。使用儿童抑郁量表（CDI）和儿童创伤后应激反应指数（CPSRI）。禁食12小时后，化学发光法测定了20名女性PTSD的女性性虐待受害者和20名健康的青少年的血液皮质醇和DHEA-S。结果：与年龄匹配的对照组相比，PTSD的女性青少年性虐待受害者的DHEA-S水平明显降低（U = 70.00，Z =-3.517，p = 0.01，r = 0.55）。 DHEA-S和CDI评分之间也存在显着负相关（Spearman r =-0.522，p <0.01）。结论：DHEA-S水平降低以及与抑郁症状的相关性是PTSD女性青少年单性创伤患者HPA轴失调的证据。现在建议对大型患者群体进行进一步研究，以最大程度地提高概括性。

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