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首页> 外文期刊>Biochemistry >Mitochondria-Targeted Plastoquinone Derivatives as Tools to Interrupt Execution of the Aging Program. 5. SkQ1 Prolongs Lifespan and Prevents Development of Traits of Senescence
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Mitochondria-Targeted Plastoquinone Derivatives as Tools to Interrupt Execution of the Aging Program. 5. SkQ1 Prolongs Lifespan and Prevents Development of Traits of Senescence

机译：针对线粒体的醌醌衍生物可作为中断执行衰老程序的工具。 5. SkQ1延长寿命并防止衰老性状的发展

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摘要

Very low (nano- and subnanomolar) concentrations of 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.
机译：发现10-（6'-plastquinquinyl）癸基三苯基phosph（SkQ1）的浓度极低（纳米和亚纳摩尔）可延长真菌（Podospora anserina），甲壳类动物（Ceriodaphnia affinis），昆虫（Drosophila melanogaster）和哺乳动物（老鼠）。在后一种情况下，如果动物生活在非无菌饲养箱中，则中值寿命将增加一倍。寿命的增加伴随着生存曲线的矩形化（早期生存比晚期生存大得多）以及典型的衰老特征消失或发育迟缓。此处和本系列以前的文章中总结的数据表明，针对线粒体的抗氧化剂SkQ1具有延缓衰老程序的执行能力，而衰老程序负责与年龄相关的衰老的发展。

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