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Fragmentomics of Natural Peptide Structures

机译：天然肽结构的片段组学

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Natural fragmentation of peptide and other chemical structures is well known. They are a significant object of biochemical investigations. In this connection, the bases and determination are given for the notion of the "fragmentome" as a set of all fragments of a single substance, as well as for global fragmentome of all chemical components of living organisms. It is described how protein-peptide fragments are formed in nature, what experimental and theoretical methods are used for their investigation, as well as mathematical characteristics of fragmentomes. Individual fragmentomes of all sub-units and of complete casein fragmentome are considered in detail. Structural and functional variety of its possible fragments was revealed by computer analysis. Formation in an organism of an exogenous-endogenous pool of oligopeptides and correlation of these data with concepts of structure-functional continuum of regulatory molecules is shown on an example of food protein fragments. Possible practical importance of the use of natural fragments in dietology, therapy, as well as in sanitary hygiene and cosmetics is noted.
机译：肽和其他化学结构的天然断裂是众所周知的。它们是生化研究的重要对象。在这方面，给出了“片段组”概念的基础和确定，该片段组是单一物质的所有片段的集合，也是活生物体所有化学成分的整体片段组的基础。它描述了蛋白质肽片段是如何在自然界中形成的，研究了哪些实验和理论方法，以及片段组的数学特征。所有亚基的单个片段组和完整的酪蛋白片段组都被详细考虑。通过计算机分析揭示了其可能片段的结构和功能多样性。在食物蛋白片段的实例上显示了在生物体中外源-内源性寡肽池的形成以及这些数据与调节分子的结构-功能连续体概念的相关性。注意到在饮食，治疗以及卫生和化妆品中使用天然碎片的可能的实际重要性。

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