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首页> 外文期刊>Nucleic Acids Research >A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains
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A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains

机译：卡哈尔人体特异性假尿苷化指导RNA由两个框H / ACA snoRNA样域组成

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摘要

Site-specific post-transcriptional conversion of uridines to pseudouridine in ribosomal RNAs and small nuclear RNAs (snRNAs) is directed by guide RNAs which possess the conserved box H and ACA sequence elements and fold into the consensus 'hairpin-hinge-hairpin-tail' secondary structure. Here, we describe an unusual mammalian pseudouridylation guide RNA, called U93, that is composed of two tandemly arranged box H/ACA RNA domains. The U93 RNA therefore carries two H and two ACA box motifs, all of which are essential for accumulation of the full-length RNA. The human U93 RNA accumulates in Cajal (coiled) bodies and it is predicted to function in pseudouridylation of the U2 spliceosomal snRNA. Our results lend further support to the notion that modification of the RNA polymerase II-transcribed spliceosomal snRNAs takes place in Cajal bodies.
机译：核糖体RNA和小核RNA（snRNA）中尿苷的位点特异性转录后转化是由具有保守的框H和ACA序列元件并折叠成共有的“发夹-铰链-发夹-尾巴”的引导RNA指导的二级结构。在这里，我们描述了一个不寻常的哺乳动物伪尿素化指导RNA，称为U93，它由两个串联排列的框H / ACA RNA域组成。因此，U93 RNA带有两个H和两个ACA盒基序，所有这些基序对于全长RNA的积累都是必不可少的。人U93 RNA积累在Cajal（螺旋形）体内，预计在U2剪接体snRNA的假尿苷化中起作用。我们的结果进一步支持了RNA聚合酶II转录的剪接体snRNA在Cajal体中发生修饰的观点。

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