TRANSCRIPTIONAL REGULATION OF THE MHC CLASS I HLA-A11 PROMOTER BY THE ZINC FINGER PROTEIN ZFX

Lharidon M; Paul P; Xerri JG; Dastot H; Dolliger C; Schmid M

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TRANSCRIPTIONAL REGULATION OF THE MHC CLASS I HLA-A11 PROMOTER BY THE ZINC FINGER PROTEIN ZFX

机译：锌指蛋白ZFX对MHC I类HLA-A11启动子的转录调控

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Regulation of the human MHC class I HLA-A11 promoter is governed by a complex array of regulatory elements. One of these elements, shown here to be critical for the transcriptional activity of the promoter, was used to screen a lambda gt11 library and allowed the identification of a cDNA which coded for the zinc finger protein ZFX. ZFX was shown to bind the sequences AGGGCCCCA and AGGCCCCGA, located respectively at positions -271 to -263 and -242 to -234 of the HLA-A11 promoter, with similar affinities through its three C-terminal zinc fingers. ZFX(575), a short isoform of ZFX, activates transcription from the HLA-A11 promoter in a Leydig cell line.

机译：人类MHC I类HLA-A11启动子的调控受一系列复杂的调控元件调控。这些元件之一，对启动子的转录活性至关重要，用于筛选λgt11文库，并鉴定出编码锌指蛋白ZFX的cDNA。显示ZFX结合序列AGGGCCCCA和AGGCCCCGA，其分别位于HLA-A11启动子的-271至-263位和-242至-234位，并通过其三个C末端锌指具有相似的亲和力。 ZFX（575）是ZFX的短型，可激活Leydig细胞系中HLA-A11启动子的转录。

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来源
《Nucleic Acids Research》 |1996年第10期|共8页
作者
Lharidon M; Paul P; Xerri JG; Dastot H; Dolliger C; Schmid M;
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正文语种 eng
中图分类细胞形态学;生物化学;
关键词
Crystal structure; Dna recognition; Binding activity; Expression; Complex; Genes; Cells; Antigens; Lines; Rules;

机译：晶体结构;Dna识别;结合活性;表达;复合体;基因;细胞;抗原;系;规则;

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专利

1. TRANSCRIPTIONAL REGULATION OF THE MHC CLASS I HLA-A11 PROMOTER BY THE ZINC FINGER PROTEIN ZFX [J] . Lharidon M, Paul P, Xerri JG, Nucleic Acids Research . 1996,第10期

机译：锌指蛋白ZFX对MHC I类HLA-A11启动子的转录调控
2. Transcriptional Regulation of the MHC Class II Trans-Activator (CIITA) Promoter III: Identification of a Novel Regulatory Region in the 5′-Untranslated Region and an Important Role for cAMP-Responsive Element Binding Protein 1 and Activating Transcription Factor-1 in CIITA-Promoter III Transcriptional Activation in B Lymphocytes [J] . Nienke van der Stoep, Edwin Quinten, Peter J. van den Elsen The journal of immunology . 2002,第9期

机译：MHC II类反式激活子（CIITA）启动子III的转录调控：5'-非翻译区的新型调控区的鉴定以及cAMP-响应元件结合蛋白1和激活转录因子1在CIITA-中的重要作用B淋巴细胞中的启动子III转录激活
3. Transcriptional Regulation of the MHC Class II Trans-Activator (CIITA) Promoter III: Identification of a Novel Regulatory Region in the 5′-Untranslated Region and an Important Role for cAMP-Responsive Element Binding Protein 1 and Activating Transcription Factor-1 in CIITA-Promoter III Transcriptional Activation in B Lymphocytes [J] . Nienke van der Stoep, Edwin Quinten, Peter J. van den Elsen The journal of immunology . 2002,第9期

机译：MHC II类反式激活子（CIITA）启动子III的转录调控：5'-非翻译区的新型调控区的鉴定以及cAMP-响应元件结合蛋白1和激活转录因子1在CIITA-中的重要作用B淋巴细胞中的启动子III转录激活
4. The influence of the background model on DNA motif prediction: An assessment for zinc finger transcription factor ZFX [C] . Lihu Andrei, Holban Stefan 10th Jubilee IEEE International Symposium on Applied Computational Intelligence and Informatics . 2015

机译：背景模型对DNA基序预测的影响：锌指转录因子ZFX的评估
5. New Vistas in Zinc Finger Biochemistry: Examining the Metal-Mediated DNA Recognition of the Neural Zinc Finger Factor/Myelin Transcription Factor Family of Non-Classical Zinc Finger Proteins and Creating Catalytic Moieties from Zinc Finger Scaffolds [D] . Besold, Angelique N. 2014

机译：锌指生物化学的新视野：检查非经典锌指蛋白的神经锌指因子/髓鞘转录因子家族的金属介导的DNA识别，并从锌指支架中产生催化部分
6. Transcriptional regulation of the MHC class I HLA-A11 promoter by the zinc finger protein ZFX. [O] . M LHaridon, P Paul, J G Xerri, 1996

机译：锌指蛋白ZFX对MHC I类HLA-A11启动子的转录调控。
7. Transcriptional regulation of the MHC class I HLA-A11 promoter by the zinc finger protein ZFX. [O] . L'Haridon, M, Paul, P, Xerri, J G, 1996

机译：锌指蛋白ZFX对MHC I类HLA-A11启动子的转录调控。
8. Regulation of Endogenous Gene Expression in Cells Using Zinc Finger Proteins. [R] . Cox, G. N., Case, C. C., Eisenberg, S. P., 2004

机译：用锌指蛋白调节细胞内源基因表达。

TRANSCRIPTIONAL REGULATION OF THE MHC CLASS I HLA-A11 PROMOTER BY THE ZINC FINGER PROTEIN ZFX

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