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首页> 外文期刊>Nucleus >Coordinating postmitotic nuclear pore complex assembly with abscission timing
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Coordinating postmitotic nuclear pore complex assembly with abscission timing

机译：与脱落时间协调有丝分裂后核孔复合体装配

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摘要

Cells divide and accurately inherit genomic and cellular content through synchronized changes in cellular organization and chromosome dynamics. Although DNA segregation, nuclear reformation and cytokinesis/ abscission temporally overlap, little is known about how these distinct events are coordinated to ensure accurate cell division. Recently, we found that disruption of postmitotic nuclear pore complex assembly, an essential aspect of the newly forming nuclear envelope, triggers an Aurora B-dependent delay in abscission. This delay is further characterized by mislocalized, aberrantly active Aurora B in the cytoplasm of midbody-stage cells. These results support a model in which an Aurora B-mediated abscission check-point provides surveillance of nuclear pore complex formation to ensure that elements of nuclear architecture are fully formed before daughter cells are physi-cally separated. Here we discuss the pro-cess of nuclear pore complex assembly, describe potential mechanisms that may explain how this process could be coordi-nated with abscission and postulate why such a checkpoint mechanism may exist.
机译：细胞通过细胞组织和染色体动力学的同步变化来分裂并准确地继承基因组和细胞的内容。尽管DNA分离，核重组和胞质分裂/脱落在时间上重叠，但对于如何协调这些不同的事件以确保准确的细胞分裂知之甚少。最近，我们发现破坏有丝分裂后的核孔复合体组装，这是新形成的核被膜的重要方面，触发了Aurora B依赖的脱落延迟。这种延迟的进一步特征是在中体阶段细胞的细胞质中定位错误，异常活跃的AuroraB。这些结果支持了一个模型，其中Aurora B介导的脱落检查点提供了对核孔复合物形成的监视，以确保在物理分离子细胞之前完全形成核结构的要素。在这里，我们讨论了核孔复合体组装的过程，描述了可能解释该过程如何与脱落协调的潜在机制，并提出了可能存在这种检查点机制的假设。

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