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Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies

机译：长非编码RNA依赖性核小体组装中的染色质重塑复合体

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摘要

Paraspeckles are subnuclear structures that assemble on nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding (lnc)RNA. Paraspeckle formation requires appropriate NEAT1 biogenesis and subsequent assembly with multiple prion-like domain (PLD) containing RNA-binding proteins. We found that SWI/SNF chromatin remodeling complexes function as paraspeckle components that interact with paraspeckle proteins (PSPs) and NEAT1. SWI/SNF complexes play an essential role in paraspeckle formation that does not require their ATP-dependent chromatin remodeling activity. Instead, SWI/SNF complexes facilitate organization of the PSP interaction network required for intact paraspeckle assembly. SWI/SNF complexes may collectively bind multiple PSPs to recruit them onto NEAT1. SWI/SNF complexes are also required for Sat III (Satellite III) lncRNA-dependent formation of nuclear stress bodies under heat shock conditions. Organization of the lncRNA-dependent omega speckle in Drosophila also depends on the chromatin remodeling complex. These findings raise the possibility that a common mechanism controls the formation of lncRNA-dependent nuclear body architecture.
机译：副斑点是在核副斑点组装转录本1（NEAT1）长的非编码（lnc）RNA上组装的亚核结构。散斑形成需要适当的NEAT1生物发生，并随后与包含RNA结合蛋白的多个病毒样结构域（PLD）组装。我们发现SWI / SNF染色质重塑复合体作为与副斑点蛋白（PSPs）和NEAT1相互作用的副斑点成分。 SWI / SNF复合物在散斑形成中起着至关重要的作用，不需要它们的ATP依赖的染色质重塑活性。取而代之的是，SWI / SNF复合体有助于完整散斑组装所需的PSP交互网络的组织。 SWI / SNF复合体可以共同绑定多个PSP，以将它们募集到NEAT1上。在热激条件下，Sat III（Satellite III）lncRNA依赖的核应力体形成也需要SWI / SNF复合物。果蝇中lncRNA依赖的ω斑点的组织也取决于染色质重塑复合物。这些发现增加了共同机制控制依赖lncRNA的核体结构形成的可能性。

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