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Lamin-B in systemic inflammation, tissue homeostasis, and aging

机译：Lamin-B在全身性炎症，组织稳态和衰老中的作用

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Gradual loss of tissue function (or homeostasis) is a natural process of aging and is believed to cause many age-associated diseases. In human epidemiology studies, the low-grade and chronic systemic inflammation in elderly has been correlated with the development of aging related pathologies. Although it is suspected that tissue decline is related to systemic inflammation, the cause and consequence of these aging phenomena are poorly understood. By studying the Drosophila fat body and gut, we have uncovered a mechanism by which lamin-B loss in the fat body upon aging induces age-associated systemic inflammation. This chronic inflammation results in the repression of gut local immune response, which in turn leads to the over-proliferation and mis-differentiation of the intestinal stem cells, thereby resulting in gut hyperplasia. Here we discuss the implications and remaining questions in light of our published findings and new observations.
机译：组织功能（或体内稳态）的逐渐丧失是衰老的自然过程，被认为会引起许多与年龄有关的疾病。在人类流行病学研究中，老年人的低度和慢性全身性炎症与衰老相关的病理学发展有关。尽管怀疑组织衰弱与全身炎症有关，但对这些衰老现象的原因和后果知之甚少。通过研究果蝇的脂肪和肠道，我们发现了一种机制，通过该机制，衰老后脂肪体内的lamin-B损失会引起与年龄相关的全身性炎症。这种慢性炎症导致肠道局部免疫反应受到抑制，进而导致肠道干细胞过度增殖和误分化，从而导致肠道增生。在这里，我们根据已发表的发现和新观察结果讨论了含义和尚待解决的问题。

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