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Nucleocytoplasmic shuttling of tRNAs and implication of the cytosolic Hsp70 system in tRNA import

机译：tRNA的胞质穿梭和胞质Hsp70系统在tRNA导入中的意义

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摘要

tRNAs, a class of non-coding RNAs essential for translation, are unique among cytosolic RNA species in that they shuttle between the nucleus and cytoplasm during their life. Although their export from the nucleus has been studied in detail, limited information on import machinery was available. Our group recently reported that Ssa2p, one of major cytosolic Hsp70s in Saccharomyces cerevisiae, acts as a crucial factor for tRNA import upon nutrient starvation. Ssa2p can bind tRNAs and a nucleoporin directly in an ATP-sensitive manner, suggesting that it acts as a nuclear import carrier for tRNAs, like importin- proteins. In vitro assays revealed that Ssa2p binds tRNA specifically but has preference for loosely folded tRNAs. In this Extra View, these features of Ssa2p as a new import factor is discussed with other recent findings related to nucleocytoplasmic transport of tRNAs reported from other groups.
机译：tRNA是翻译必不可少的一类非编码RNA，在胞质RNA物种中是独特的，因为它们在生命中会在核和细胞质之间穿梭。尽管已经对它们从核中的出口进行了详细研究，但有关进口机器的信息却很少。我们的小组最近报告说，Ssa2p是酿酒酵母中主要的胞质Hsp70s之一，是营养不足时tRNA导入的关键因素。 Ssa2p可以以ATP敏感的方式直接结合tRNA和核孔蛋白，表明它作为tRNA的核输入载体，如importin蛋白。体外测定显示，Ssa2p特异结合tRNA，但优先选择松散折叠的tRNA。在此Extra View中，将Ssa2p作为新的导入因子的这些特征与其他最近发现的与其他组报道的tRNA的核质转运相关的问题进行了讨论。

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