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首页> 外文期刊>Nucleus >Moving and positioning the nucleus in skeletal muscle - one step at a time
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Moving and positioning the nucleus in skeletal muscle - one step at a time

机译：移动和定位骨骼肌中的核-一次仅一步

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摘要

Nuclear movement and positioning within cells has become an area of great interest in the past few years due to the identification of different molecular mechanisms and functions in distinct organisms and contexts. One extreme example occurs during skeletal muscle development and regeneration. Skeletal muscles are composed of individual multinucleated myofibers with nuclei positioned at their periphery. Myofibers are formed by fusion of mononucleated myoblasts and during their development, successive nuclear movements and positioning events have been described. The position of the nuclei in myofibers is important for muscle function. Interestingly, during muscle regeneration and in some muscular diseases, nuclei are positioned in the center of the myofiber. In this review, we discuss the multiple mechanisms of nuclear positioning that occur during myofiber formation and regeneration. We also discuss the role of nuclear positioning for skeletal muscle function.
机译：在过去的几年中，由于在不同的生物体和环境中鉴定了不同的分子机制和功能，细胞内的核运动和定位已成为人们非常关注的领域。一个极端的例子是骨骼肌发育和再生。骨骼肌由单个多核肌纤维组成，其核位于其外围。肌纤维是由单核成肌细胞融合形成的，在其发育过程中，已经描述了连续的核运动和定位事件。肌纤维中核的位置对于肌肉功能很重要。有趣的是，在肌肉再生过程中和某些肌肉疾病中，细胞核位于肌纤维的中央。在这篇综述中，我们讨论了在肌纤维形成和再生过程中发生的核定位的多种机制。我们还讨论了核定位对骨骼肌功能的作用。

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