DNA topology and transcription

Fedor Kouzine; David Levens; Laura Baranello

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DNA topology and transcription

机译：DNA拓扑和转录

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摘要

Chromatin is a complex assembly that compacts DNA inside the nucleus while providing the necessary level of accessibility to regulatory factors conscripted by cellular signaling systems. In this superstructure, DNA is the subject of mechanical forces applied by variety of molecular motors. Rather than being a rigid stick, DNA possesses dynamic structural variability that could be harnessed during critical steps of genome functioning. The strong relationship between DNA structure and key genomic processes necessitates the study of physical constrains acting on the double helix. Here we provide insight into the source, dynamics, and biology of DNA topological domains in the eukaryotic cells and summarize their possible involvement in gene transcription. We emphasize recent studies that might inspire and impact future experiments on the involvement of DNA topology in cellular functions.

机译：染色质是一个复杂的程序集，它压缩细胞核内的DNA，同时提供对细胞信号系统所征集的调节因子的必需水平的可及性。在这种上层建筑中，DNA是各种分子马达施加的机械力的主题。 DNA不是坚固的棍棒，而是具有动态的结构变异性，可以在基因组功能的关键步骤中加以利用。 DNA结构与关键基因组过程之间的密切关系有必要研究作用于双螺旋的物理约束。在这里，我们提供了真核细胞中DNA拓扑域的来源，动态和生物学的见解，并总结了它们可能参与基因转录。我们强调最近的研究可能会启发和影响DNA拓扑结构参与细胞功能的未来实验。

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《Nucleus》 |2014年第3期|共8页
作者
Fedor Kouzine; David Levens; Laura Baranello;
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正文语种 eng
中图分类细胞生物学;
关键词
DNA topoisomerases; DNA topological domain; DNA topology; torsional stress; transcription;

机译：DNA拓扑异构酶;DNA拓扑结构域;DNA拓扑结构;扭转应力;转录;

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专利

1. HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology. [J] . Bagga R, Michalowski S, Sabnis R, Nucleic Acids Research . 2000,第13期

机译：HMG I / Y通过改变DNA拓扑结构来调节DNA和染色质上的远程增强子依赖性转录。
2. HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology [J] . Beverly M. Emerson, Jack D. Griffith, Rajesh Bagga, Nucleic acids research . 2000,第13期

机译：HMG I / Y通过改变DNA拓扑来调节DNA和染色质上的远程增强子依赖性转录
3. Chemical acetylation of mitochondrial transcription factor A occurs on specific lysine residues and affects its ability to change global DNA topology [J] . Fang Yuan, Akimoto Masaru, Mayanagi Kouta, Mitochondrion . 2020,第1期

机译：线粒体转录因子A的化学乙酰化发生在特定的赖氨酸残基上，并影响其改变全局DNA拓扑的能力
4. SIZE AND TOPOLOGY OF EXGENOUS DNA AS DETERMINANT FACTORS OF TRANSGENE TRANSCRIPTION IN MAMMALIAN CELLS [C] . Jun Yamazaki, Hiroyuki Kamiya, Hideyoshi Harashima Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：外源DNA的大小和拓扑结构作为哺乳动物细胞中转基因转录的决定因素
5. Analyzing DNA topology and transcription in Salmonella enterica serovar typhimurium during dichotomous growth. [D] . Booker, Betty M. 2010

机译：在二分体生长过程中分析肠炎沙门氏菌鼠伤寒沙门氏菌的DNA拓扑结构和转录。
6. Cell-free transcription at 95 degrees: thermostability of transcriptional components and DNA topology requirements of Pyrococcus transcription. [O] . C Hethke, A Bergerat, W Hausner, 1999

机译：95度无细胞转录：热球菌转录组分的热稳定性和DNA拓扑结构要求。
7. HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology [O] . Bagga, Rajesh, Michalowski, Susan, Sabnis, Rohit, 2000

机译：HMG I / Y通过改变DNA拓扑结构来调节DNA和染色质上的远程增强子依赖性转录

DNA topology and transcription

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