DNA torsion as a feedback mediator of transcription and chromatin dynamics

Sheila S Teves; Steven Henikoff

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DNA torsion as a feedback mediator of transcription and chromatin dynamics

机译：DNA扭转作为转录和染色质动力学的反馈介质

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The double helical structure of DNA lends itself to topological constraints. Many DNA-based processes alter the topological state of DNA, generating torsional stress, which is efficiently relieved by topoisomerases. Maintaining this topological balance is crucial to cell survival, as excessive torsional strain risks DNA damage. Here, we review the mechanisms that generate and modulate DNA torsion within the cell. In particular, we discuss how transcription-generated torsional stress affects Pol II kinetics and chromatin dynamics, highlighting an emerging role of DNA torsion as a feedback mediator of torsion-generating processes.

机译：DNA的双螺旋结构使其自身具有拓扑约束。许多基于DNA的过程会改变DNA的拓扑状态，产生扭转应力，而拓扑异构酶可有效缓解扭转应力。维持这种拓扑平衡对于细胞存活至关重要，因为过度的扭转应变可能会损害DNA。在这里，我们回顾了在细胞内产生和调节DNA扭转的机制。特别是，我们讨论了转录产生的扭转应力如何影响Pol II动力学和染色质动力学，突出了DNA扭转作为扭转产生过程的反馈介体的新兴作用。

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《Nucleus》 |2014年第3期|共8页
作者
Sheila S Teves; Steven Henikoff;
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正文语种 eng
中图分类细胞生物学;
关键词
torsional stress; nucleosome turnover; nascent RNA; topoisomerase; RNA Polymerase II;

机译：扭转应力;核小体更新;新生RNA;拓扑异构酶;RNA聚合酶II;

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1. DNA torsion as a feedback mediator of transcription and chromatin dynamics [J] . Sheila S Teves, Steven Henikoff Nucleus . 2014,第3期

机译：DNA扭转作为转录和染色质动力学的反馈介质
2. Soma influences GSC progeny differentiation via the cell adhesion-mediated steroid-let-7-Wingless signaling cascade that regulates chromatin dynamics Soma influences GSC progeny differentiation via the cell adhesion-mediated steroid-let-7-Wingless signaling cascade that regulates chromatin dynamics Soma influences GSC progeny differentiation via the cell adhesion-mediated steroid-let-7-Wingless signaling cascade that regulates chromatin dynamics [J] . Halyna R. Shcherbata, Annekatrin K?nig Biology Open . 2015,第3期

机译：索马通过调节染色质动力学的细胞粘附介导的类固醇-let-7-无翅信号级联影响GSC后代分化索马通过调节染色质动力学的细胞粘附介导的类固醇-let-7-无翅信号级联影响GSC后代分化。通过细胞粘附介导的类固醇-let-7-Wingless信号级联反应调节染色质动力学，从而使GSC后代分化
3. DNA torsional stress propagates through chromatin fiber and participates in transcriptional regulation [J] . Lavelle C Nature structural & molecular biology . 2008,第2期

机译：DNA扭转应力通过染色质纤维传播并参与转录调控
4. Predicting transcription factor site occupancy using DNA sequence intrinsic and cell-type specific chromatin features [C] . Sunil Kumar, Philipp Bucher Asia-Pacific Bioinformatics Conference . 2016

机译：使用DNA序列固有和细胞型特异性染色质特征预测转录因子位点占用
5. An Open and Shut Genome: The Dynamic Relationship between DNA Sequence, Transcription Factors, and Chromatin in Saccharomyces cerevisiae. [D] . Gossett, Andrea J. 2011

机译：开放和关闭的基因组：酿酒酵母中DNA序列，转录因子和染色质之间的动态关系。
6. DNA torsion as a feedback mediator of transcription and chromatin dynamics [O] . Sheila S Teves, Steven Henikoff 2014

机译：DNA扭转作为转录和染色质动力学的反馈介质
7. Doxorubicin, DNA torsion, and chromatin dynamics [O] . Yang Fan, Teves Sheila S., Kemp Christopher J., 2014

机译：阿霉素，DNA扭转和染色质动力学

DNA torsion as a feedback mediator of transcription and chromatin dynamics

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