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Transcriptional regulation at the yeast nuclear envelope

机译：酵母核膜的转录调控

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摘要

The spatial organization of the genome inside the nucleus affects many nuclear processes, such as DNA replication, DNA repair and gene transcription. In metazoans, the nuclear periphery harbors mainly repressed genes that associate with the nuclear lamina. This review discusses how peripheral positioning is connected to transcriptional regulation in yeasts. Tethering of reporter genes to the nuclear envelope was found to result in transcriptional silencing. Similarly, repression of the silent mating type loci and subtelomeric genes is influenced by their position close to the nuclear envelope. In contrast, active genes are bound by nucleoporins and inducible genes associate with the nuclear pore complex upon activation. Taken together, these results portray the nuclear envelope as a platform for transcriptional regulation, both through activation at nuclear pores and silencing at the nuclear envelope.
机译：细胞核内基因组的空间组织会影响许多核过程，例如DNA复制，DNA修复和基因转录。在后生动物中，核的外围主要带有与核层相关的被抑制的基因。这篇评论讨论了外周定位如何与酵母中的转录调控相关。发现报告基因与核膜的束缚导致转录沉默。类似地，沉默交配型基因座和亚端粒基因的抑制受它们靠近核被膜的位置的影响。相反，活性基因被核孔蛋白结合，并且诱导型基因在激活时与核孔复合物结合。总之，这些结果将核被膜描绘为转录调控的平台，通过在核孔处激活和在核被膜处沉默来实现。

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