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Co-transcriptional nuclear actin dynamics

机译：共转录核肌动蛋白动力学

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摘要

Actin is a key player for nuclear structure and function regulating both chromosome organization and gene activity. In the cell nucleus actin interacts with many different proteins. Among these proteins several studies have identified classical nuclear factors involved in chromatin structure and function, transcription and RNA processing as well as proteins that are normally involved in controlling the actin cytoskel?ton. These discoveries have raised the possibility that nuclear actin performs its multi task activities through tight interactions with different sets of proteins. This high degree of promiscuity in the spectrum of protein-to-protein interactions correlates well with the conformational plasticity of actin and the ability to undergo regulated changes in its polymerization states. Several of the factors involved in controlling head-to-tail actin polymerization have been shown to be in the nucleus where they seem to regulate gene activity. By focusing on the multiple tasks performed by actin and actin-binding proteins, possible models of how actin dynamics controls the different phases of the RNA polymerase II transcription cycle are being identified.
机译：肌动蛋白是调节染色体组织和基因活性的核结构和功能的关键参与者。在细胞核中，肌动蛋白与许多不同的蛋白质相互作用。在这些蛋白质中，几项研究已经确定了涉及染色质结构和功能，转录和RNA加工的经典核因子，以及通常参与控制肌动蛋白细胞骨架的蛋白质。这些发现增加了核肌动蛋白通过与不同组蛋白的紧密相互作用来执行其多任务活动的可能性。蛋白质与蛋白质相互作用谱中的这种高度混杂性与肌动蛋白的构象可塑性以及在其聚合态下进行调节变化的能力密切相关。已显示出控制头尾肌动蛋白聚合的几个因素似乎在细胞核中，它们似乎在调节基因的活性。通过专注于肌动蛋白和肌动蛋白结合蛋白执行的多个任务，正在确定肌动蛋白动力学如何控制RNA聚合酶II转录周期不同阶段的可能模型。

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